Rangel-Sandoval Diana Karina, Guerrero-Becerra Lucia, Lomas-Soria Consuelo, Rico-Chávez Amanda Kim, Cervantes-Chávez José Antonio, Reyes-Castro Luis Antonio, Morales-Miranda Angélica, Feregrino-Pérez Ana Angélica
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Campus Aeropuerto, Carretera a Chichimequillas s/n, Anillo Vial Fray Junípero Serra, Km 8, Querétaro 76000, Mexico.
Facultad de Ingeniería, Universidad Autónoma de Querétaro, Campus Amazcala, Carretera a Chichimequillas Km 1 s/n, Amazcala, El Marqués 76265, Mexico.
Pharmaceuticals (Basel). 2025 Apr 18;18(4):593. doi: 10.3390/ph18040593.
Timbe () is a legume recognized for its environmental benefits, such as soil restoration, wildlife nutrition, and the presence of biologically active compounds. This study investigates the antioxidant, pharmacological, and antimicrobial properties of Timbe. The total phenolic content, flavonoids, and condensed tannins from Timbe flowers, seeds, and pods were quantified, and their antioxidant activity was evaluated using the DPPH and ABTS assays. Enzymatic activities were assessed through α-amylase, α-glucosidase, and ACE-I inhibition, and antimicrobial properties were tested against various bacterial strains. The pods and flowers exhibited higher antioxidant capacities compared to seeds, effectively neutralizing free radicals. Flavonoids and condensed tannins showed positive correlations with antioxidant activity and the inhibition of α-amylase and α-glucosidase, suggesting the potential benefits of these metabolites in blood glucose control. Timbe also demonstrated ACE-I inhibition, particularly the flowers. Regarding antimicrobial activity, the pods displayed moderate inhibition against , , and . The results indicate that different parts of Timbe (flowers, seeds, and pods) possess significant therapeutic potential for preventing and treating metabolic disorders and bacterial infections.
蒂姆贝（Timbe）是一种豆科植物，因其对环境有益而闻名，例如土壤修复、为野生动物提供营养以及含有生物活性化合物。本研究调查了蒂姆贝的抗氧化、药理和抗菌特性。对蒂姆贝的花、种子和豆荚中的总酚含量、黄酮类化合物和缩合单宁进行了定量，并使用DPPH和ABTS法评估了它们的抗氧化活性。通过α-淀粉酶、α-葡萄糖苷酶和ACE-I抑制来评估酶活性，并针对各种细菌菌株测试抗菌特性。与种子相比，豆荚和花表现出更高的抗氧化能力，能有效中和自由基。黄酮类化合物和缩合单宁与抗氧化活性以及α-淀粉酶和α-葡萄糖苷酶的抑制呈正相关，表明这些代谢产物在控制血糖方面具有潜在益处。蒂姆贝还表现出ACE-I抑制作用，尤其是花。关于抗菌活性，豆荚对[具体细菌名称1]、[具体细菌名称2]和[具体细菌名称3]表现出中等程度的抑制。结果表明，蒂姆贝的不同部分（花、种子和豆荚）在预防和治疗代谢紊乱及细菌感染方面具有显著的治疗潜力。
