Okabe T, Yamagata K, Fujisawa M, Takaku F, Hidaka H, Umezawa Y
Biochem Biophys Res Commun. 1987 Jun 30;145(3):1211-6. doi: 10.1016/0006-291x(87)91566-x.
Induction of vascular endothelial cells with pituitary fibroblast growth factor (FGF) provoked an increase in angiotensin converting enzyme activity. The stimulatory effect of FGF on ACE activity was dose-dependent (ED50 = 1.0 ng/ml). Our results suggest a possible role for pituitary FGF in regulation of ACE production in vascular endothelial cells.
用垂体成纤维细胞生长因子（FGF）诱导血管内皮细胞，会引起血管紧张素转换酶活性增加。FGF对ACE活性的刺激作用呈剂量依赖性（半数有效剂量=1.0纳克/毫升）。我们的结果提示垂体FGF在调节血管内皮细胞中ACE产生方面可能发挥作用。
