体外培养的血管内皮细胞中，成纤维细胞生长因子对血管紧张素转换酶的诱导作用。
Induction by fibroblast growth factor of angiotensin converting enzyme in vascular endothelial cells in vitro.
作者信息
Okabe T, Yamagata K, Fujisawa M, Takaku F, Hidaka H, Umezawa Y
出版信息
Biochem Biophys Res Commun. 1987 Jun 30;145(3):1211-6. doi: 10.1016/0006-291x(87)91566-x.
PMID:3038093
Abstract
Induction of vascular endothelial cells with pituitary fibroblast growth factor (FGF) provoked an increase in angiotensin converting enzyme activity. The stimulatory effect of FGF on ACE activity was dose-dependent (ED50 = 1.0 ng/ml). Our results suggest a possible role for pituitary FGF in regulation of ACE production in vascular endothelial cells.
摘要
用垂体成纤维细胞生长因子（FGF）诱导血管内皮细胞，会引起血管紧张素转换酶活性增加。FGF对ACE活性的刺激作用呈剂量依赖性（半数有效剂量=1.0纳克/毫升）。我们的结果提示垂体FGF在调节血管内皮细胞中ACE产生方面可能发挥作用。
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