T图和rs-EPI DWI在皮肌炎中的诊断价值
The diagnostic value of T maps and rs-EPI DWI in dermatomyositis.
作者信息
Ran Jun, Ji Suqiong, Morelli John N, Wu Gang, Li Xiao Ming
机构信息
1 Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
2 Department of Neurology, Tongji Hospital, Huazhong University of Science and Technology , Wuhan , China.
出版信息
Br J Radiol. 2019 Feb;92(1094):20180715. doi: 10.1259/bjr.20180715. Epub 2018 Nov 14.
OBJECTIVE
: To explore and confirm feasibility the T maps and readout-segmented echoplanar imaging (rs-EPI) diffusion-weighted imaging (DWI) characteristics of the thigh muscles for dermatomyositis (DM) patients.
METHODS
: This study was approved by the University Institutional Review and written informed consent was obtained from all subjects before enrollment (trial registration number: TJ-C20121221). 28 patients with DM proven by diagnostic criteria were enrolled in the study along with 9 healthy control subjects. Conventional MR, T maps and rs-EPI DWI were obtained for all subjects. Both of T and apparent diffusion coefficient (ADC) values for thigh muscles were compared between the DM and healthy control groups. The amount of inflammation and fatty infiltration were respectively assigned a score of 0 to 5 for all thigh muscles. The Kruskal-Wallis tests were utilized and the Spearman correlation coefficients models were used to correlate both of the T and ADC value with non-quantitative MRI. P-values <0.05 reflected statistical significance.
RESULTS
: Both of the T and ADC values among all affected muscles, unaffected muscles and the control groups were respectively statistical difference (p < 0.05 respectively), the T value of affected muscles was greater than that of unaffected muscles in DM patients (p < 0.05). Differences of the T value in DM patients among the combination the edematous with fatty infiltration score groups were statistically significant (p < 0.001). The T value showed a significant correlation with the non-quantitative MRI score for edema and fatty infiltration.
CONCLUSIONS
: T maps may have a specialized ability for the detection severity of damaged muscles in comparison to the rs-EPI DWI sequence.
ADVANCES IN KNOWLEDGE
: A new application of rs-EPI DWI is proposed for DM patients. First, comparison of T maps and rs-EPI DWI technology are applied for DM. The results demonstrate that T maps may be more potential value in determining the severity of diseased muscles for DM patients.
目的
探讨并确认皮肌炎（DM）患者大腿肌肉的T图及读出分段回波平面成像（rs-EPI）扩散加权成像（DWI）特征的可行性。
方法
本研究经大学机构审查委员会批准，所有受试者在入组前均签署了书面知情同意书（试验注册号：TJ-C20121221）。纳入28例符合诊断标准的DM患者及9名健康对照者。对所有受试者进行常规磁共振成像、T图及rs-EPI DWI检查。比较DM组与健康对照组大腿肌肉的T值及表观扩散系数（ADC）值。对所有大腿肌肉的炎症和脂肪浸润程度分别进行0至5分的评分。采用Kruskal-Wallis检验，并使用Spearman相关系数模型将T值和ADC值与非定量MRI进行相关性分析。P值<0.05表示具有统计学意义。
结果
所有受累肌肉、未受累肌肉及对照组之间的T值和ADC值均存在统计学差异（P值均<0.05），DM患者中受累肌肉的T值高于未受累肌肉（P<0.05）。DM患者中水肿与脂肪浸润评分组合的T值差异具有统计学意义（P<0.001）。T值与水肿和脂肪浸润的非定量MRI评分显著相关。
结论
与rs-EPI DWI序列相比，T图在检测受损肌肉严重程度方面可能具有特殊能力。
知识进展
提出了rs-EPI DWI在DM患者中的新应用。首先，将T图和rs-EPI DWI技术应用于DM的比较。结果表明，T图在确定DM患者患病肌肉的严重程度方面可能更具潜在价值。
Zotero 插件