Wake Forest School of Medicine, Department of Neurology, One Medical Center Blvd, Winston Salem, NC 27157, USA.
Wake Forest School of Medicine, Department of Neurology, One Medical Center Blvd, Winston Salem, NC 27157, USA.
Mult Scler Relat Disord. 2019 Jan;27:131-132. doi: 10.1016/j.msard.2018.10.015. Epub 2018 Oct 22.
Alemtuzumab administration is known to cause secondary autoimmune disease but has not been associated with the development of neurologic autoimmune conditions. Lambert-Eaton myasthenic syndrome (LEMS) is caused by autoantibodies directed against calcium channels on the neuromuscular junction.
We report a case of a patient with relapsing-remitting multiple sclerosis (RRMS) treated with alemtuzumab who develop generalized weakness initially attributed to progression of MS but eventually determined to be due to LEMS.
Alemtuzumab treatment can result in the development of neurologic autoimmune conditions that could mimic MS progression.
阿仑单抗给药已知会引起继发性自身免疫疾病，但与神经自身免疫疾病的发展无关。Lambert-Eaton 肌无力综合征（LEMS）是由针对神经肌肉接头钙通道的自身抗体引起的。
我们报告了一例复发性多发性硬化症（RRMS）患者，该患者用阿仑单抗治疗后出现全身无力，最初归因于 MS 进展，但最终确定是由于 LEMS。
阿仑单抗治疗可导致神经自身免疫疾病的发展，这些疾病可能模仿 MS 进展。
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