Tanaka S, Shimamoto K, Ando T, Nakahashi Y, Ura N, Hosoda S, Ishida H, Yamaji I, Yokoyama T, Masuda A
Clin Exp Hypertens A. 1987;9(2-3):605-9. doi: 10.3109/10641968709164231.
In four patients with essential hypertension and one patient with renovascular hypertension, decreases in blood pressure and plasma angiotensin II levels, and increases in plasma renin activity and plasma kinin levels were observed during eight days of alacepril treatment. Significant correlations between the changes in mean arterial pressure and those in plasma angiotensin II or kinin levels were observed positively or negatively, respectively, in the essential hypertensives. These findings suggest that the hypotensive effect of alacepril might be caused mainly by a decrease in plasma angiotensin II levels and, at least in part, by an increase in plasma kinin levels.
在4例原发性高血压患者和1例肾血管性高血压患者中，在阿拉普利治疗的8天期间观察到血压和血浆血管紧张素II水平降低，血浆肾素活性和血浆激肽水平升高。在原发性高血压患者中，分别观察到平均动脉压变化与血浆血管紧张素II或激肽水平变化之间存在显著的正相关或负相关。这些发现表明，阿拉普利的降压作用可能主要是由血浆血管紧张素II水平降低引起的，至少部分是由血浆激肽水平升高引起的。
