单次口服卡托普利可能无法改善原发性醛固酮增多症的筛查。

Single oral administration of captopril may not bring an improvement in screening of primary aldosteronism.

作者信息

Muratani H, Abe I, Tomita Y, Ueno M, Takishita S, Kawazoe N, Tsuchihashi T, Kawasaki T, Fujishima M

出版信息

Clin Exp Hypertens A. 1987;9(2-3):611-4. doi: 10.3109/10641968709164232.

DOI:10.3109/10641968709164232

Abstract

Plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were measured in 19 cases with primary aldosteronism (PA) and 72 with essential hypertension (EHT) to differentiate the two disorders in the following conditions: after overnight recumbency (basal state) and after oral administration of captopril. Screening criteria were determined in order to pick up all of PA patients as positive. After the captopril administration, the specificity of a criterion based on the combination of PAC and PAC/PRA ratio was 93% and positive predictive value 79%. This criterion was superior to other conventional screening methods. However, higher specificity (97%) and positive predictive value (90%) were obtained from a combination criterion based on the basal PAC and PAC/PRA ratio. The single oral administration of captopril may not bring an improvement in the screening of PA.

摘要

对19例原发性醛固酮增多症（PA）患者和72例原发性高血压（EHT）患者测定了血浆肾素活性（PRA）和血浆醛固酮浓度（PAC），以在以下情况下鉴别这两种疾病：过夜卧位后（基础状态）以及口服卡托普利后。确定了筛查标准，以便将所有PA患者均判定为阳性。服用卡托普利后，基于PAC和PAC/PRA比值组合的标准的特异性为93%，阳性预测值为79%。该标准优于其他传统筛查方法。然而，基于基础PAC和PAC/PRA比值的组合标准具有更高的特异性（97%）和阳性预测值（90%）。单次口服卡托普利可能无法改善PA的筛查。