National Health and Medical Research Council Centre of Excellence in Severe Asthma, Newcastle, NSW, Australia.
Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, NSW, Australia.
Respirology. 2019 Apr;24(4):352-360. doi: 10.1111/resp.13428. Epub 2018 Nov 1.
Physical activity (PA) in obstructive airway diseases (OAD) is likely to be impaired but this has not been extensively studied outside of chronic obstructive pulmonary disease (COPD). We describe PA levels in severe asthma and bronchiectasis compared to moderate-severe COPD and to controls, and tested the cross-sectional associations of PA (steps/day) with shared disease characteristics in the OAD group.
Adults with OAD (severe asthma = 62, COPD = 67, bronchiectasis = 60) and controls (n = 63) underwent a multidimensional assessment, including device-measured PA levels.
The OAD group included 189 participants (58.7% females), with median (interquartile range) age of 67 (58-72) years and mean forced expiratory volume in the first second (FEV ) % predicted of 69.4%. Demographic characteristics differed between groups. Compared to controls (52.4% females, aged 55 (34-64) years, median 7640 steps/day), those with severe asthma, bronchiectasis and COPD accumulated less steps/day: median difference of -2255, -2289, and -4782, respectively (P ≤ 0.001). Compared to COPD, severe asthma and bronchiectasis participants accumulated more steps/day: median difference of 2375 and 2341, respectively (P ≤ 0.001). No significant differences were found between the severe asthma and bronchiectasis group. Exercise capacity, FEV % predicted, dyspnoea and systemic inflammation differed between groups, but were each significantly associated with steps/day in OAD. In the multivariable model adjusted for all disease characteristics, exercise capacity and FEV % predicted remained significantly associated.
PA impairment is common in OAD. The activity level was associated with shared characteristics of these diseases. Interventions to improve PA should be multifactorial and consider the level of impairment and the associated characteristics.
体力活动（PA）在阻塞性气道疾病（OAD）中可能受损，但在慢性阻塞性肺疾病（COPD）之外，这方面尚未得到广泛研究。我们描述了严重哮喘和支气管扩张症患者与中重度 COPD 患者和对照组相比的 PA 水平，并检测了 OAD 组中 PA（步数/天）与共同疾病特征的横断面相关性。
患有 OAD（严重哮喘=62 例，COPD=67 例，支气管扩张症=60 例）和对照组（n=63 例）的成年人接受了多维评估，包括设备测量的 PA 水平。
OAD 组包括 189 名参与者（58.7%为女性），中位（四分位间距）年龄为 67（58-72）岁，第一秒用力呼气量（FEV ）%预测值为 69.4%。组间人口统计学特征不同。与对照组（52.4%女性，年龄 55（34-64）岁，中位数 7640 步/天）相比，严重哮喘、支气管扩张症和 COPD 患者的步数/天更少：中位数差值分别为-2255、-2289 和-4782（P≤0.001）。与 COPD 相比，严重哮喘和支气管扩张症患者的步数/天更多：中位数差值分别为 2375 和 2341（P≤0.001）。严重哮喘和支气管扩张症组之间未发现显著差异。运动能力、FEV %预测值、呼吸困难和全身炎症在各组之间不同，但在 OAD 中均与步数/天显著相关。在调整所有疾病特征的多变量模型中，运动能力和 FEV %预测值仍然与步数/天显著相关。
PA 受损在 OAD 中很常见。活动水平与这些疾病的共同特征有关。改善 PA 的干预措施应该是多方面的，并考虑到损伤程度和相关特征。
