心力衰竭患者的药物依从性与生活质量的关系。
Relationship of medication adherence and quality of life among heart failure patients.
机构信息
Clinical Pharmacy Division, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; Faculty of Pharmacy, Chiang Mai University, Suthep, Muang, Chiang Mai, Chiang Mai 50200, Thailand.
Clinical Pharmacy Division, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
出版信息
Heart Lung. 2019 Mar-Apr;48(2):105-110. doi: 10.1016/j.hrtlng.2018.09.009. Epub 2018 Oct 30.
BACKGROUND
Little is known regarding the relationship between medication adherence and quality of life in heart failure patients. We therefore aimed to examine the nature of relationship between medication adherence and quality of life.
METHODS
A prospective, cross-sectional study of chronic heart failure patients with reduced ejection fraction was performed at a tertiary-care, university hospital in Thailand. Quality of life and medication adherence were assessed using the Minnesota Living with Heart Failure Questionnaire (MLHFQ) and Morisky Medication Adherence Scale-8 (MMAS-8), respectively. Relationship of MLHFQ and MMAS-8 were examined using Spearman's correlation coefficient and multiple regression analysis for covariates adjustment.
RESULTS
Among 180 patients, 38.3%, 50.0% and 11.7% were found to have high, medium and poor adherence, respectively. For quality of life, the overall median score on the MLHFQ was relatively low. A positive relationship was identified between medication adherence and quality of life. After covariate adjustment, medication adherence was found to have the strongest relationship with quality of life, compared to other covariates.
CONCLUSIONS
Medication adherence has a small and positive relationship with quality of life among heart failure patients.
背景
关于心力衰竭患者药物依从性与生活质量之间的关系知之甚少。因此，我们旨在研究药物依从性与生活质量之间的关系。
方法
在泰国的一家三级护理、大学医院对射血分数降低的慢性心力衰竭患者进行了前瞻性、横断面研究。使用明尼苏达州心力衰竭生活质量问卷（MLHFQ）和 Morisky 药物依从性量表-8（MMAS-8）分别评估生活质量和药物依从性。使用 Spearman 相关系数和多元回归分析调整协变量来检查 MLHFQ 和 MMAS-8 之间的关系。
结果
在 180 名患者中，分别有 38.3%、50.0%和 11.7%的患者被发现具有高、中、低依从性。对于生活质量，MLHFQ 的总体中位数得分相对较低。药物依从性与生活质量之间存在正相关关系。在调整协变量后，与其他协变量相比，药物依从性与生活质量的关系最强。
结论
心力衰竭患者的药物依从性与生活质量呈正相关。
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