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链脲佐菌素诱导的糖尿病大鼠神经束膜钠钾ATP酶活性

Perineurial sodium-potassium-ATPase activity in streptozotocin-diabetic rats.

作者信息

Llewelyn J G, Thomas P K

出版信息

Exp Neurol. 1987 Aug;97(2):375-82. doi: 10.1016/0014-4886(87)90097-5.

DOI:10.1016/0014-4886(87)90097-5
PMID:3038588
Abstract

Perineurial sodium-potassium-ATPase activity was estimated in streptozotocin-diabetic rats and compared with that in control animals. Total ATPase activity was found to be reduced by 34% and ouabain-sensitive ATPase activity by 53%. This finding is significant in relation to the putative role of the perineurium as a metabolically active perifascicular diffusion barrier that regulates the composition of the endoneurial fluid, as is its possible relevance to the occurrence of endoneurial edema in diabetes.

摘要

对链脲佐菌素诱导的糖尿病大鼠的神经束膜钠钾 - ATP酶活性进行了评估,并与对照动物进行比较。发现总ATP酶活性降低了34%,哇巴因敏感的ATP酶活性降低了53%。这一发现对于神经束膜作为调节神经内膜液成分的具有代谢活性的束周扩散屏障的假定作用具有重要意义,同样也与糖尿病中神经内膜水肿的发生可能相关。

相似文献

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Perineurial sodium-potassium-ATPase activity in streptozotocin-diabetic rats.链脲佐菌素诱导的糖尿病大鼠神经束膜钠钾ATP酶活性
Exp Neurol. 1987 Aug;97(2):375-82. doi: 10.1016/0014-4886(87)90097-5.
2
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Sodium-potassium-ATPase activity in the dorsal root ganglia of rats with streptozotocin-induced diabetes.链脲佐菌素诱导的糖尿病大鼠背根神经节中的钠钾ATP酶活性
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Reduced Na+ + K+-ATPase activity in peripheral nerve of streptozotocin-diabetic rats: a role for protein kinase C?链脲佐菌素诱导的糖尿病大鼠外周神经中钠钾ATP酶活性降低:蛋白激酶C的作用?
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引用本文的文献

1
Experimental galactose neuropathy: quantitative changes in intramembranous particles in fracture faces of the perineurium.实验性半乳糖神经病:神经束膜断裂面内膜内颗粒的定量变化
J Anat. 1993 Feb;182 ( Pt 1)(Pt 1):105-8.
2
Adenosine triphosphatase in nerves and ganglia of rats with streptozotocin-induced diabetes or galactosaemia; effects of aldose reductase inhibition.链脲佐菌素诱导的糖尿病或半乳糖血症大鼠神经和神经节中的三磷酸腺苷酶;醛糖还原酶抑制的作用
Diabetologia. 1988 Jun;31(6):379-84. doi: 10.1007/BF02341507.
3
Sodium, potassium adenosine triphosphatase activity in peripheral nerve tissue of galactosaemic rats. Effect of aldose reductase inhibition.
半乳糖血症大鼠外周神经组织中钠钾三磷酸腺苷酶活性。醛糖还原酶抑制的作用。
Diabetologia. 1987 Dec;30(12):971-2. doi: 10.1007/BF00295885.