实验性半乳糖神经病：神经束膜断裂面内膜内颗粒的定量变化
Experimental galactose neuropathy: quantitative changes in intramembranous particles in fracture faces of the perineurium.
作者信息
Beamish N G, Stolinski C, Thomas P K, King R H
机构信息
Department of Anatomy and Cell Biology, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, UK.
出版信息
J Anat. 1993 Feb;182 ( Pt 1)(Pt 1):105-8.
Peripheral nerves in rats fed a diet containing 40% galactose develop endoneurial oedema related to the accumulation of interstitial galactitol and sodium. Biochemical studies of the perineurium in galactose neuropathy indicate an increase in membrane bound Na+/K(+)-ATPase activity. The present study has analysed the intramembraneous particles (IMPs) on the P membrane fracture faces of the perineurium in galactose-fed rats and has demonstrated a significant increase in the density of IMPs. This finding may reflect changes in the perineurial cell membranes in galactose neuropathy, such as increased membrane bound Na+/K(+)-ATPase activity.
喂食含40%半乳糖饮食的大鼠外周神经会出现与间质半乳糖醇和钠积累相关的神经内膜水肿。半乳糖性神经病中神经束膜的生化研究表明膜结合的Na⁺/K⁺-ATP酶活性增加。本研究分析了喂食半乳糖的大鼠神经束膜P膜断裂面上的膜内颗粒（IMPs），并证明IMPs密度显著增加。这一发现可能反映了半乳糖性神经病中神经束膜细胞膜的变化，如膜结合的Na⁺/K⁺-ATP酶活性增加。
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