具有异常特征的“假性淋巴细胞性”白血病：超微结构、免疫学、细胞遗传学及分子研究

'Pseudo-lymphoid' leukaemia with unusual features: ultrastructural, immunological, cytogenetic and molecular studies.

作者信息

Matutes E, Foroni L, Amin S, de Oliveira M P, Brito-Babapulle V, Luzzatto L, Catovsky D

出版信息

Eur J Haematol. 1987 Apr;38(4):303-9. doi: 10.1111/j.1600-0609.1987.tb00002.x.

DOI:10.1111/j.1600-0609.1987.tb00002.x

Abstract

An unusual case of 'pseudo-lymphoid' leukaemia is described. The leukaemic cells resembled small, mature lymphocytes but lacked B- and T-cell membrane markers as well as immunoglobulin (Ig) and T-cell receptor gene rearrangements. They showed, instead, features of early myeloid cells since they expressed 2 myeloid antigens, CDW13 and My9, and displayed peroxidase activity demonstrable by electron microscopy (EM) on unfixed cells. Cytogenetic studies showed monosomy 5, t(4;17) (p12;p11), t(2;3)(p23;q14) and an abnormal chromosome 12. Abnormalities of chromosomes 4 and 5 have been previously associated with 'pseudo-lymphoid' leukaemias. This case illustrates the value of sensitive methods for the characterization of blast cells and for the precise diagnosis of leukaemias with apparent 'lymphoid' morphology.

摘要

本文描述了一例不寻常的“假性淋巴细胞性”白血病病例。白血病细胞类似于小的成熟淋巴细胞，但缺乏B细胞和T细胞膜标志物以及免疫球蛋白（Ig）和T细胞受体基因重排。相反，它们表现出早期髓样细胞的特征，因为它们表达两种髓样抗原CDW13和My9，并且在未固定的细胞上通过电子显微镜（EM）显示出可证实的过氧化物酶活性。细胞遗传学研究显示5号染色体单体、t(4;17)(p12;p11)、t(2;3)(p23;q14)以及一条异常的12号染色体。4号和5号染色体异常先前已与“假性淋巴细胞性”白血病相关。该病例说明了敏感方法在原始细胞特征鉴定以及对具有明显“淋巴细胞样”形态的白血病进行精确诊断方面的价值。