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NALL-1,一种具有过氧化物酶活性的急性淋巴细胞白血病细胞系。

NALL-1, an acute lymphoblastic leukemia cell line with peroxidase activity.

作者信息

Yourno J, Samsonoff W A, Willey A, Burkhart P, Lizzi F, Tartaglia A

出版信息

In Vitro. 1984 Nov;20(11):884-8. doi: 10.1007/BF02619636.

Abstract

All cells examined from the non-B, non-T acute lymphoblastic leukemia cell line, NALL-1, stained positive both for terminal deoxynucleotidyl transferase and for common ALL antigen. In addition, peroxidase activity was detected by light microscopy in 55 to 75% of cells and peroxidase-positive granules were detected ultrastructurally in greater than 80% of cells. Peroxidase activity in NALL-1 may result from derepression of peroxidase genes or clonal proliferation of a biphenotypic precursor cell.

摘要

从非B、非T急性淋巴细胞白血病细胞系NALL-1中检测的所有细胞,末端脱氧核苷酸转移酶和常见ALL抗原染色均呈阳性。此外,通过光学显微镜在55%至75%的细胞中检测到过氧化物酶活性,并且在超80%的细胞中通过超微结构检测到过氧化物酶阳性颗粒。NALL-1中的过氧化物酶活性可能是由于过氧化物酶基因的去抑制或双表型前体细胞的克隆增殖所致。

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