Massaia M, Pioppo P, Dianzani U, Guerra M G, Peyretti F, Pileri A, Tamponi G
Eur J Haematol. 1987 Apr;38(4):310-4. doi: 10.1111/j.1600-0609.1987.tb00003.x.
It has been recently demonstrated that ecto-5'nucleotidase (5'NT) activity is significantly decreased in the peripheral blood lymphocytes (PBL) of homosexual men. This paper reports a study of PBL 5'NT activity in 38 hemophiliacs at risk for the acquired immunodeficiency syndrome (AIDS). The enzyme activity was correlated to the immunologic and virologic data. T-cell subset distribution was unbalanced and directly correlated with the cumulative amount of AHF infused. PBL 5'NT activity, however, was similar to that of healthy controls. 6 patients displayed serum antibodies to the human immunodeficiency virus (HIV) but no decrease in PBL 5'NT activity. In conclusion, these data indicate that both heavily treated and seropositive as well as untreated hemophiliacs have normal PBL 5'NT activity. This striking dissimilarity between homosexual men and hemophiliacs suggests that some immunologic alterations leading to 5'NT deficiency occur in the former only.
最近有研究表明，同性恋男性外周血淋巴细胞（PBL）中的外切5'-核苷酸酶（5'NT）活性显著降低。本文报道了对38名有获得性免疫缺陷综合征（AIDS）风险的血友病患者的PBL 5'NT活性的研究。酶活性与免疫学和病毒学数据相关。T细胞亚群分布不均衡，且与输入的抗血友病因子（AHF）累积量直接相关。然而，PBL 5'NT活性与健康对照组相似。6名患者显示出针对人类免疫缺陷病毒（HIV）的血清抗体，但PBL 5'NT活性并未降低。总之，这些数据表明，经过大量治疗的、血清反应阳性的以及未经治疗的血友病患者的PBL 5'NT活性均正常。同性恋男性和血友病患者之间的这种显著差异表明，导致5'NT缺乏的一些免疫改变仅发生在前者身上。
