Dianzani U, Pileri A, Bianchi A, Camponi A, Tamponi G, Massaia M
Department of Medicine and Experimental Oncology, University of Turin, Italy.
Eur J Haematol. 1988 Oct;41(4):334-40. doi: 10.1111/j.1600-0609.1988.tb00206.x.
Subset distribution, ecto-5'nucleotidase (5'NT) activity, and the generation of allospecific cytotoxic T lymphocytes (CTL) were investigated in peripheral blood T lymphocytes from 39 hemophilia A patients divided into three groups: group A and group B (HIV-patients with CD4:CD8 ratio less than 1 and greater than 1 respectively), and group C (HIV + patients). 5'NT activity was significantly decreased compared with healthy controls in groups B and C. In group B, this deficiency was attributable to expansion of CD8 + CD11 + suppressor cells. In group C, activated (HLA-DR+) CD8+ cells were also present and contributed to 5'NT deficiency. The suppressor cell expansion seemed to be mainly related to AHF infusions, whereas HLA-DR expression was related to HIV infection. CD11+ and HLA-DR+ cells were also expanded in the CD4+ subpopulation of all three groups, whereas CD4+ CD28+ lymphocytes were significantly decreased in group C only. Lastly, alloreactive cytotoxicity was decreased in group B and was normal in groups A and C.
对39例甲型血友病患者外周血T淋巴细胞的亚群分布、外切5'-核苷酸酶（5'NT）活性及同种特异性细胞毒性T淋巴细胞（CTL）的产生进行了研究。这些患者被分为三组：A组和B组（分别为HIV阴性患者，CD4:CD8比值小于1和大于1），以及C组（HIV阳性患者）。与健康对照组相比，B组和C组的5'NT活性显著降低。在B组，这种缺陷归因于CD8 + CD11 + 抑制细胞的扩增。在C组，活化的（HLA-DR +）CD8 + 细胞也存在，并导致5'NT缺乏。抑制细胞的扩增似乎主要与抗血友病因子（AHF）输注有关，而HLA-DR表达与HIV感染有关。CD11 + 和HLA-DR + 细胞在所有三组的CD4 + 亚群中也有扩增，而只有C组的CD4 + CD28 + 淋巴细胞显著减少。最后，B组的同种反应性细胞毒性降低，A组和C组正常。
