Szczudlik A, Lypka A
Funct Neurol. 1986 Jul-Sep;1(3):245-52.
The short, overnight, metyrapone test with plasma ACTH and beta-endorphin (beta-EP) determination has been performed in patients with migraine, other forms of headache, and healthy volunteers. A rise in plasma ACTH and beta-EP after metyrapone occurred in all investigated subjects. The rate of increase varied greatly from one individual to the other, but no significant differences between the mean values of plasma ACTH and beta-EP in different groups of headache patients and volunteers were observed. Three months of nadolol therapy in migraine patients caused a significant increase in plasma ACTH and decrease in beta-EP concentrations. Findings support the view that migraine patients do not have a primary dysfunction of the hypothalamus-pituitary-adrenal (HPA) axis as demonstrated by methods currently in use.
我们对偏头痛患者、其他类型头痛患者以及健康志愿者进行了短期的过夜甲吡酮试验，并测定了血浆促肾上腺皮质激素（ACTH）和β-内啡肽（β-EP）。所有受试对象在使用甲吡酮后血浆ACTH和β-EP均升高。个体之间的升高速率差异很大，但未观察到不同组头痛患者和志愿者的血浆ACTH和β-EP平均值有显著差异。偏头痛患者接受三个月的纳多洛尔治疗后，血浆ACTH显著升高，β-EP浓度降低。这些发现支持了这样一种观点，即目前使用的方法表明偏头痛患者不存在下丘脑-垂体-肾上腺（HPA）轴的原发性功能障碍。
