Department of Chemistry , Southern University of Science and Technology , Shenzhen , 518055 , P. R. China.
ACS Sens. 2018 Nov 26;3(11):2408-2414. doi: 10.1021/acssensors.8b00918. Epub 2018 Nov 13.
To enrich the recipes of ion-selective nanosensors, graphene quantum dots (GQDs) were integrated into ionophore-based fluorescent nanosensors with exquisite selectivity and high sensitivity for Na and K. The unique property of GQDs gave the nanosensors ultrasmall size (ca. 10 nm), high brightness, good biocompatibility, and potential pH sensing possibility. At pH 7.4, the sensors exhibited a detection range from 0.1 mM to 1 M for Na and from 3 μM to 1 mM for K. The nanosensors were successfully applied to blood serum and urine samples. Chemically induced intracellular sodium concentration change in HeLa cells was also qualitatively monitored.
为丰富离子选择性纳米传感器的食谱，将石墨烯量子点（GQDs）集成到基于离子载体的荧光纳米传感器中，该传感器对 Na 和 K 具有精致的选择性和高灵敏度。GQDs 的独特性质赋予了纳米传感器超小的尺寸（约 10nm）、高亮度、良好的生物相容性和潜在的 pH 传感可能性。在 pH 值为 7.4 时，传感器对 Na 的检测范围从 0.1mM 到 1M，对 K 的检测范围从 3μM 到 1mM。该纳米传感器成功应用于血清和尿液样本。还定性监测了 HeLa 细胞中化学诱导的细胞内钠离子浓度变化。
Zotero 插件