Doly M, Bonhomme B, Braquet P, Chabrier P E, Meyniel G
Immunopharmacology. 1987 Jun;13(3):189-94. doi: 10.1016/0162-3109(87)90057-9.
The effects of (R)PAF-acether have been tested on the isolated rat retina model. Results indicate that (R)PAF-acether inhibits the electrophysiological response (electroretinogram) elicited on isolated retina by a brief light flash. Immediately after the administration of (R)PAF-acether, an irreversible decrease of the electroretinogram b-wave amplitude is observed. This effect is dose-dependent (2 X 10(-11) M, 2 X 10(-9) M, 2 X 10(-7) M) and partially inhibited by simultaneous administration of Ginkgolide B (BN 52021; 2 X 10(-5) M). These results suggest the existence of (R)PAF-acether-specific receptors inside the retina.
已在离体大鼠视网膜模型上测试了（R）-血小板活化因子（PAF-乙醚）的作用。结果表明，（R）-PAF-乙醚抑制短暂闪光在离体视网膜上引发的电生理反应（视网膜电图）。给予（R）-PAF-乙醚后立即观察到视网膜电图b波振幅不可逆降低。这种效应呈剂量依赖性（2×10⁻¹¹M、2×10⁻⁹M、2×10⁻⁷M），并被同时给予银杏内酯B（BN 52021；2×10⁻⁵M）部分抑制。这些结果表明视网膜内存在（R）-PAF-乙醚特异性受体。
