Doly M, Braquet P, Bonhomme B, Meyniel G
Int J Tissue React. 1987;9(1):33-7.
Results of experiments performed on rat isolated retina indicate that platelet-activating factor (PAF) is able to inhibit the functional response of the retina electroretinogram (ERG) recorded in response to a brief light flash. In the presence of PAF, the ERG b-wave amplitude decreases according to a dose-dependent (2.10(-11) M; 2.10(-9) M; 2.10(-7) M) process. This effect is partially inhibited by the simultaneous administration of a Ginkgo biloba extract (GBE, 10 mg/l) or Ginkgolide B (BN 52021, 2.10(-5)M). The authors interpret these results with reference to the main mechanism of the membrane signal triggered by PAF, namely the activation of phosphatidylinositol cycle with the formation of inositol-triphosphate, the inhibition of the light-induced response of the retina by administration of inositol-triphosphate, and the antagonistic effect of GBE and BN 52021 on specific PAF-receptors demonstrated on other models. Thus specific PAF-receptors may exist at the level of the retina, which suggests that they are also present in the brain.
在大鼠离体视网膜上进行的实验结果表明，血小板活化因子（PAF）能够抑制视网膜电图（ERG）对短暂闪光的功能反应。在PAF存在的情况下，ERG的b波振幅根据剂量依赖性（2.10（-11）M；2.10（-9）M；2.10（-7）M）过程而降低。同时给予银杏叶提取物（GBE，10mg/l）或银杏内酯B（BN 52021，2.10（-5）M）可部分抑制这种效应。作者参照PAF触发的膜信号的主要机制来解释这些结果，即磷脂酰肌醇循环的激活与三磷酸肌醇的形成、通过给予三磷酸肌醇抑制视网膜的光诱导反应，以及GBE和BN 52021在其他模型上显示出的对特定PAF受体的拮抗作用。因此，在视网膜水平可能存在特定的PAF受体，这表明它们在大脑中也存在。
