Department of Plastic Reconstructive and Aesthetic Surgery, University Hospital Amiens, Amiens, France.
Aesthet Surg J. 2019 May 16;39(6):NP189-NP201. doi: 10.1093/asj/sjy303.
Pectus excavatum (PE) is sometimes associated with psychological and physiological difficulties influencing a patient's quality of life. Treatment with a hyaluronic acid (HA)-based gel may benefit patients and be an alternative to other more invasive treatments.
The authors sought to evaluate the effectiveness in terms of satisfaction, duration, and safety of HA gel treatment for PE including impact on quality of life.
Males ≥18 years having PE without functional problems received HA gel injections (50 - 150 mL) at the site of deformity and in some cases at the medial pectoralis muscle borders to optimize the aesthetic result. Follow-up visits were performed after 1, 3, 6, 12, and 24 months with optional retreatment at the 24-month visit including a 1-month follow-up. Evaluations included Pectus Excavatum Evaluation Questionnaire, patient satisfaction, magnetic resonance imaging, and safety assessments.
The treatment significantly improved patients' self-esteem (P < 0.001) and psychosocial function (P ≤ 0.038) throughout the study, as assessed by Pectus Excavatum Evaluation Questionnaire. Patients were satisfied with the aesthetic outcome and considered the treatment mild in terms of level of pain during injection. Treatment effects were maintained up to 24 months and 58% of the HA gel remained at this visit, shown by Magnetic Resonance Imaging measurements. The treatment was well tolerated.
Treatment of PE with HA gel improved patient quality of life related to self-esteem and psychosocial functioning including aesthetically pleasing results. The treatment may also offer benefits in terms of safety and tolerability compared with other treatments.
漏斗胸（PE）有时与影响患者生活质量的心理和生理困难有关。使用透明质酸（HA）凝胶治疗可能使患者受益，并成为其他更具侵入性治疗方法的替代方法。
作者旨在评估 HA 凝胶治疗 PE 的有效性，包括满意度、持续时间和安全性，以及对生活质量的影响。
≥18 岁且无功能问题的男性患者在畸形部位和某些情况下在胸肌内缘接受 HA 凝胶注射（50-150mL），以优化美容效果。在 1、3、6、12 和 24 个月时进行随访，在 24 个月时进行可选的重复治疗，并在 1 个月时进行随访。评估包括漏斗胸评估问卷、患者满意度、磁共振成像和安全性评估。
治疗在整个研究过程中显著改善了患者的自尊心（P<0.001）和社会心理功能（P≤0.038），通过漏斗胸评估问卷进行评估。患者对美容效果满意，并认为注射时疼痛程度较轻。治疗效果可维持长达 24 个月，在本次就诊时仍有 58%的 HA 凝胶保留，磁共振成像测量结果显示。治疗耐受性良好。
HA 凝胶治疗 PE 可改善与自尊心和社会心理功能相关的患者生活质量，包括美观的结果。与其他治疗方法相比，该治疗方法在安全性和耐受性方面可能具有优势。
