Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida.
Centro de Referência e Treinamento em DST/AIDS, Programa Estadual de DST/AIDS.
J Infect Dis. 2019 Feb 15;219(5):703-710. doi: 10.1093/infdis/jiy533.
Genital wart (GW) incidence is high among men. The percentage and rate at which subsequent GW events occur are understudied. The purpose of this study was to describe the rate of subsequent GWs, associated human papillomavirus (HPV) types, and time to subsequent GW event among unvaccinated men.
The study was nested within a multinational prospective HPV natural history study of men aged 18-70 years in the United States, Mexico, and Brazil, examined every 6 months for a median follow-up of 50.4 months. Subsequent GW events were defined as GWs detected after ≥16 weeks of the prior event.
Forty-four percent of men experienced ≥1 GW following the initial episode. Men with ≥2 subsequent events were at highest risk of continued GW experiences, with as high as 10 postinitial GW events. The incidence rate of each subsequent GW increased with increasing events (incidence of first subsequent event was 13.1 vs 36.6/1000 person-months for the fourth event). The proportion of GWs among HPV-6 and/or -11-positive patients remained constant across events. Approximately 63%-69% were positive for ≥1 of the 9-valent HPV vaccine types.
These data highlight the high burden of GWs among men across the lifespan and the need for vaccination to prevent multiple GW episodes.
生殖器疣（GW）在男性中的发病率很高。随后 GW 事件发生的百分比和发生率尚未得到充分研究。本研究的目的是描述未接种疫苗男性中随后 GW 的发生率、相关的人乳头瘤病毒（HPV）类型以及随后 GW 事件发生的时间。
该研究嵌套在一项针对美国、墨西哥和巴西 18-70 岁男性的多国家前瞻性 HPV 自然史研究中，中位随访时间为 50.4 个月，每 6 个月检查一次。随后 GW 事件定义为在前一次事件后≥16 周检测到 GW。
44%的男性在首次发病后经历了≥1 次 GW。有≥2 次后续事件的男性发生 GW 的风险最高，高达 10 次 GW 发生在初次 GW 之后。每个后续 GW 的发病率随着事件的增加而增加（首次后续 GW 的发病率为 13.1 比第 4 次 GW 的发病率为 36.6/1000 人月）。HPV-6 和/或 -11 阳性患者的 GW 比例在各次 GW 中保持不变。大约 63%-69%的患者对 9 价 HPV 疫苗类型中的至少一种呈阳性。
这些数据突出了 GW 在男性一生中的高负担，需要接种疫苗来预防多次 GW 发作。
