Department of Dermatology and Venereology, Bispebjerg Hospital, DK-2400 Copenhagen, Denmark. E-mail:
Acta Derm Venereol. 2021 Jul 13;101(7):adv00497. doi: 10.2340/00015555-3858.
Renal transplant recipients have increased risk of human papilloma virus-related anogenital (pre)cancers. Less is known about their risk of anogenital warts. The aim of this study was to estimate the prevalence and odds of anogenital warts in renal transplant recipients compared with immunocompetent controls, and to assess risk factors for intra- and perianal warts in renal transplant recipients. The study examined 248 renal transplant recipients and 250 controls for cutaneous and mucosal anogenital warts. Participants completed a questionnaire on lifestyle and sexual habits. For external anogenital warts (including penile, vulvar and perianal warts), renal transplant recipients had higher prevalence and odds than controls, both in men (8.1% vs 1.6%, adjusted odds ratio (ORadjusted)=5.09, 95% confidence interval (95% CI), 1.03-25.04) and women (11.3% vs 1.6%, ORadjusted=8.09, 95% CI 1.69-38.82). For intra-anal warts, there was no clear pattern of higher odds in renal transplant recipients than controls. Current smoking and having had receptive anal sex increased the risk of intra-/perianal warts in renal transplant recipients. In conclusion, renal transplant recipients in this study had higher odds of external anogenital warts than controls.
肾移植受者患人乳头瘤病毒相关的肛门生殖器（前）癌症的风险增加。对于肛门生殖器疣，人们了解较少。本研究旨在估计肾移植受者与免疫功能正常的对照者相比发生肛门生殖器疣的患病率和比值比，并评估肾移植受者发生肛门内和肛周疣的危险因素。本研究检查了 248 例肾移植受者和 250 例对照者的皮肤和粘膜肛门生殖器疣。参与者完成了关于生活方式和性习惯的问卷。对于外部肛门生殖器疣（包括阴茎、外阴和肛周疣），男性和女性肾移植受者的患病率和比值比均高于对照组（分别为 8.1% vs 1.6%，调整比值比（ORadjusted）=5.09，95%置信区间（95% CI），1.03-25.04）。对于肛门内疣，肾移植受者的比值比没有明显高于对照组的趋势。目前吸烟和接受过肛门性交会增加肾移植受者肛门内/肛周疣的风险。总之，本研究中的肾移植受者发生外部肛门生殖器疣的比值比高于对照组。
