Institut de Recherches Internationales Servier, Suresnes (J.A.B.), and Institut de Recherches Servier, Croissy-sur-Seine, France (G.F.)
Institut de Recherches Internationales Servier, Suresnes (J.A.B.), and Institut de Recherches Servier, Croissy-sur-Seine, France (G.F.).
J Pharmacol Exp Ther. 2019 Jan;368(1):59-65. doi: 10.1124/jpet.118.253260. Epub 2018 Nov 2.
In the 1980s, researchers used binding studies to show that there is a melatonin binding site in addition to the receptors described previously. It was first termed ML and then, in 1999, Purification efforts led to its identification as quinone reductase 2. Several lines of evidence support the notion that is the same as quinone reductase 2, including the detection and characterization of whenever quinone reductase 2 was added to various systems under various conditions. This evidence is discussed in this review, which summarizes the results of relevant cellular and animal experiments. The recent discovery that the quinone reductase 2 enzyme can be partly membrane-associated may unite the current body of evidence and allow us to conclude definitively that the third melatonin binding site, , is indeed quinone reductase 2.
在上世纪 80 年代，研究人员通过结合研究表明，除了之前描述的受体之外，还有一个褪黑素结合位点。它最初被命名为 ML，然后在 1999 年，纯化工作使其被鉴定为醌还原酶 2。有几条证据支持的观点，即与醌还原酶 2 相同，包括在各种条件下将醌还原酶 2 添加到各种系统中时检测和表征。本综述讨论了这一证据，总结了相关的细胞和动物实验结果。最近发现，醌还原酶 2 酶可以部分与膜结合，这可能将当前的证据统一起来，并使我们能够最终确定第三个褪黑素结合位点，即醌还原酶 2。
