Department of Pharmacy-Pharmaceutical Sciences, University of Bari "Aldo Moro", 70126. Bari, Italy.
Mini Rev Med Chem. 2024;24(5):546-565. doi: 10.2174/1389557523666230627140816.
Oxidative stress has been reported to be involved in the onset and development of several diseases, including neurodegenerative and cardiovascular disorders, some types of cancer, and diabetes. Therefore, finding strategies to detoxify free radicals is an active area of research. One of these strategies is the use of natural or synthetic antioxidants. In this context, melatonin (MLT) has been proven to possess most of the required characteristics of an efficient antioxidant. In addition, its protection against oxidative stress continues after being metabolized, since its metabolites also exhibit antioxidant capacity. Based on the appealing properties of MLT and its metabolites, various synthetic analogues have been developed to obtain compounds with higher activity and lower side effects. This review addresses recent studies with MLT and related compounds as potential antioxidants.
氧化应激被报道与多种疾病的发生和发展有关，包括神经退行性疾病和心血管疾病、某些类型的癌症和糖尿病。因此，寻找解毒自由基的策略是一个活跃的研究领域。其中一种策略是使用天然或合成抗氧化剂。在这种情况下，褪黑素（MLT）已被证明具有有效抗氧化剂的大多数必需特性。此外，其在被代谢后仍能对氧化应激提供保护，因为其代谢产物也具有抗氧化能力。基于 MLT 及其代谢物的吸引人的特性，已经开发出各种合成类似物，以获得具有更高活性和更低副作用的化合物。本综述讨论了最近关于 MLT 及其相关化合物作为潜在抗氧化剂的研究。
