Goodwin G M, Fraser S, Stump K, Fairburn C G, Elliott J M, Cowen P J
J Affect Disord. 1987 May-Jun;12(3):267-74. doi: 10.1016/0165-0327(87)90037-1.
Platelet monoamine receptor binding was determined in normal male and female subjects before and at the end of a 2- to 3-week weight reducing diet (1200 kcal daily). Dieting was associated with an increase in platelet binding sites for both [3H]yohimbine and [125I]iodolysergic acid diethylamide (iodoLSD). The affinity at the platelet [125I]iodoLSD binding site was reduced. In contrast, [3H]imipramine binding was unchanged. These results have important implications for studies that employ platelet binding as a peripheral marker of neurotransmitter function in psychiatric illness.
