Hu Zuojian, Chen Huaping, Huang Li, Chen Siyuan, Huang Zhili, Qin Shanzi, Zhong Jianing, Qin Xue, Li Shan
Department of Laboratory Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
J Clin Lab Anal. 2019 Mar;33(3):e22705. doi: 10.1002/jcla.22705. Epub 2018 Nov 2.
Our aim intended to determine the relationship between hematological parameters (neutrophil-to-lymphocyte ratio [NLR], platelet-to-lymphocyte ratio [PLR], and eosinophil-to-lymphocyte ratio [ELR]) and ancylostomiasis.
There were 140 patients with ancylostomiasis and 159 healthy controls enrolled in this study. All data were collected from electronic medical records of the First Affiliated Hospital of Guangxi Medical University.
The levels of NLR, PLR, and ELR in ancylostomiasis patients were significantly higher than those in the healthy controls (all P = 0.000). A receiver operating characteristic curve was generated to assess the diagnostic efficacy of these three hematological parameters. ELR (AUC = 0.850; sensitivity = 75.00%; specificity = 86.80%) showed the superior AUC than those of NLR (AUC = 0.718; sensitivity = 53.57%; specificity = 88.68%) and PLR (AUC = 0.806; sensitivity = 68.57%; specificity = 86.79%), respectively. A multivariate regression model using the two selected indices (RBC and ELR) was established with the model's sensitivity and specificity reached 82.86% and 96.23%, respectively. In the ancylostomiasis patient group, NLR (r = -0.452, P = 0.000) and PLR (r = -0.357, P = 0.000) were reversely associated with eosinophils.
The pretreatment levels of the three hematological parameters (NLR, PLR, and ELR) may serve as valuable indicators for distinguishing patients with ancylostomiasis from healthy controls. NLR and PLR are negatively associated with the previous indicator, eosinophils.
本研究旨在确定血液学参数（中性粒细胞与淋巴细胞比值[NLR]、血小板与淋巴细胞比值[PLR]以及嗜酸性粒细胞与淋巴细胞比值[ELR]）与钩虫病之间的关系。
本研究纳入了140例钩虫病患者和159例健康对照。所有数据均收集自广西医科大学第一附属医院的电子病历。
钩虫病患者的NLR、PLR和ELR水平显著高于健康对照（均P = 0.000）。绘制了受试者工作特征曲线以评估这三个血液学参数的诊断效能。ELR（曲线下面积[AUC]=0.850；敏感性=75.00%；特异性=86.80%）的AUC优于NLR（AUC = 0.718；敏感性=53.57%；特异性=88.68%）和PLR（AUC = 0.806；敏感性=68.57%；特异性=86.79%）。使用两个选定指标（红细胞和ELR）建立了多变量回归模型，该模型的敏感性和特异性分别达到82.86%和96.23%。在钩虫病患者组中，NLR（r = -0.452，P = 0.000）和PLR（r = -0.357，P = 0.000）与嗜酸性粒细胞呈负相关。
三个血液学参数（NLR、PLR和ELR）的预处理水平可能作为区分钩虫病患者与健康对照的有价值指标。NLR和PLR与先前的指标嗜酸性粒细胞呈负相关。
