基于核磁共振的代谢组学方法评价天麻对慢性萎缩性胃炎的防治作用。
Nuclear magnetic resonance-based metabolomics approach to evaluate preventive and therapeutic effects of Gastrodia elata Blume on chronic atrophic gastritis.
机构信息
Center of Molecular Metabolism, Nanjing University of Science and Technology, 200 Xiaolingwei Street, Nanjing, 210094, China.
Center of Molecular Metabolism, Nanjing University of Science and Technology, 200 Xiaolingwei Street, Nanjing, 210094, China.
出版信息
J Pharm Biomed Anal. 2019 Feb 5;164:231-240. doi: 10.1016/j.jpba.2018.10.035. Epub 2018 Oct 28.
Chronic atrophic gastritis (CAG) is one of the most common digestive system diseases worldwide which defined by WHO as initial step of cancer. Gastrodia elata Blume (GEB) is a traditional herbal with multiple pharmacological activities which was widely used in Asian countries. This study aims to explore the preventive and therapeutical effects of Gastrodia elata Blume on auto-immune induced CAG in rats. Tissues of stomachs were collected and submitted to H NMR-based metabolomics analysis and histopathological inspection. The biochemical indexes of MDA, SOD, GSH, NO and XOD were measured. Gastrodia elata Blume could apparently ameliorate the damaged gastric glands and the biochemical parameters, enhance gastric acid secretion, and significantly relieve the inflammation of the stomach. Orthogonal signal correction-partial least squares-discriminant analysis (OSC-PLS-DA) of NMR profiles and correlation network analysis revealed that Gastrodia elata Blume could effectively treat CAG via regulating energy and purine metabolisms, and by anti-oxidation and anti-inflammation effects.
慢性萎缩性胃炎（CAG）是全球最常见的消化系统疾病之一，被世界卫生组织定义为癌症的初始步骤。天麻（GEB）是一种具有多种药理活性的传统草药，在亚洲国家被广泛使用。本研究旨在探讨天麻对大鼠自身免疫性 CAG 的防治作用。采集胃组织进行基于 H NMR 的代谢组学分析和组织病理学检查。测定 MDA、SOD、GSH、NO 和 XOD 的生化指标。天麻可明显改善受损的胃腺和生化参数，促进胃酸分泌，明显缓解胃部炎症。NMR 图谱的正交信号校正-偏最小二乘判别分析（OSC-PLS-DA）和相关网络分析表明，天麻通过调节能量和嘌呤代谢，以及抗氧化和抗炎作用，有效治疗 CAG。
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