超越组蛋白乙酰化——书写和擦除组蛋白酰化。

Beyond histone acetylation-writing and erasing histone acylations.

机构信息

MOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University, Beijing 100084, China.

出版信息

Curr Opin Struct Biol. 2018 Dec;53:169-177. doi: 10.1016/j.sbi.2018.10.001. Epub 2018 Nov 2.

DOI:10.1016/j.sbi.2018.10.001

PMID:30391813

Abstract

Histone post-translational modifications are crucial epigenetic mechanisms regulating a variety of biological events. Besides histone lysine acetylation, a repertoire of acylation types have been identified, including formylation, propionylation, butyrylation, crotonylation, 2-hydroxyisobutyrylation, β-hydroxybutyrylation, succinylation, malonylation, glutarylation and benzoylation. From a structural perspective, here we summarize the writers and erasers of histone acylations and explain the molecular basis of these enzymes catalyzing non-acetyl histone acylations with a focus on histone crotonylation and β-hydroxybutyrylation. Histone acylation readout, non-histone acylations and metabolic regulation are also discussed in this review.

摘要

组蛋白翻译后修饰是调控多种生物学事件的关键表观遗传机制。除了组蛋白赖氨酸乙酰化，还鉴定了一系列酰化类型，包括甲酰化、丙酰化、丁酰化、巴豆酰化、2-羟基异丁酰化、β-羟基丁酰化、琥珀酰化、丙二酰化、戊二酰化和苯甲酰化。从结构角度来看，在这里我们总结了组蛋白酰化的写入器和擦除器，并解释了这些酶催化非乙酰化组蛋白酰化的分子基础，重点是组蛋白巴豆酰化和β-羟基丁酰化。本文还讨论了组蛋白酰化的读出、非组蛋白酰化和代谢调控。