Kayıkçıoğlu Meral, Tokgözoğlu Lale, Kılıçkap Mustafa, Göksülük Hüseyin, Karaaslan Doruk, Özer Necla, Abacı Adnan, Yılmaz Mehmet Birhan, Barçın Cem, Ateş Kenan, Bayram Fahri, Şahin Mahmut, Ural Dilek
Department of Cardiology, Ege University Faculty of Medicine, İzmir, Turkey.
Turk Kardiyol Dern Ars. 2018 Oct;46(7):556-574. doi: 10.5543/tkda.2018.23450.
Dyslipidemias, primarily hypercholesterolemia, are independent and strong predictors of cardiovascular (CV) events. The frequency of dyslipidemia is very important in terms of determining CV prevention policies. In order to determine the up-to-date frequency of CV risk factors in Turkey, a meta-analysis of the epidemiologic studies carried out in the last 15 years was performed. This article presents the results on the dyslipidemia data including hypercholesterolemia principally.
Epidemiological studies conducted during the last 15 years and having the potential to represent the general population in Turkey were searched in databases (Ovid Medline, Web of Science Core Collection, and Turkish Academic Network and Information Center [ULAKBIM]) and web pages (Ministry of Health, Turkey Statistical Institute, Turkish Society of Cardiology, Nephrology and Endocrinology Associations). A total of 7 studies including lipid data were found. Systematic review and meta-analysis of the studies with low bias score were performed. Crude values of the prevalence of hypercholeterolemia, hypertriglyceridemia and low HDL and mean lipid levels were calculated. Random effects model was used in meta-analysis.
The prevalence of hypercholesterolemia defined as a LDLcholesterol >130 and/or ≥130 mg/dL, was 29.1% (95% CI 23.6-35.0) in the general population, 30.2% in females (%95 CI 24.7-36.1), and 27.8% in males (95% CI 22.3-33.6). The prevalence of low HDLcholesterol (≤50 mg/dL for females and ≤40 mg/dL for males) was calculated as 46.1% (95% CI 42.4-49.9) in the whole group, 50.7% (95% CI 47.7-53.6) in females and 41.1% (95% CI 36.1-46.3) in males. The prevalence of hypertriglyceridemia (>150 mg/dL) was 36.5% (95% CI 30.6-42.5) in general, 32.0% (95% GA 26.6-37.8) in females and 41.3% (95% CI 34.9-47.8) in males.
Dyslipidemia constitutes a major public health problem in Turkey. In the adult population, almost 3 of 10 have hypercholesterolemia, one of 2 has a low HDL-cholesterol, and 1 of 3 has high triglycerides levels.
血脂异常，主要是高胆固醇血症，是心血管（CV）事件的独立且强有力的预测因素。血脂异常的发生率对于确定心血管疾病预防政策非常重要。为了确定土耳其心血管危险因素的最新发生率，对过去15年进行的流行病学研究进行了荟萃分析。本文主要介绍了包括高胆固醇血症在内的血脂异常数据的结果。
在数据库（Ovid Medline、科学网核心合集以及土耳其学术网络与信息中心[ULAKBIM]）和网页（土耳其卫生部、土耳其统计局、土耳其心脏病学会、肾脏病学会和内分泌学会）中搜索过去15年进行的、有可能代表土耳其普通人群的流行病学研究。共找到7项包含血脂数据的研究。对偏倚得分较低的研究进行系统评价和荟萃分析。计算高胆固醇血症、高甘油三酯血症和低高密度脂蛋白血症患病率的原始值以及平均血脂水平。荟萃分析采用随机效应模型。
定义为低密度脂蛋白胆固醇>130和/或≥130mg/dL的高胆固醇血症在普通人群中的患病率为29.1%（95%CI 23.6 - 35.0），女性为30.2%（95%CI 24.7 - 36.1），男性为27.8%（95%CI 22.3 - 33.6）。低高密度脂蛋白胆固醇（女性≤50mg/dL，男性≤40mg/dL）在整个群体中的患病率计算为46.1%（95%CI 42.4 - 49.9），女性为50.7%（95%CI 47.7 - 53.6），男性为41.1%（95%CI 36.1 - 46.3）。高甘油三酯血症（>150mg/dL）的总体患病率为36.5%（95%CI 30.6 - 42.5），女性为32.0%（95%CI 26.6 - 37.8），男性为41.3%（95%CI 34.9 - 47.8）。
血脂异常在土耳其构成了一个主要的公共卫生问题。在成年人群中，近十分之三的人患有高胆固醇血症，二分之一的人高密度脂蛋白胆固醇低，三分之一的人甘油三酯水平高。
