Kelly S J, Franklin K B
Life Sci. 1987 Aug 10;41(6):789-94. doi: 10.1016/0024-3205(87)90460-7.
Rats subjected to prolonged restraint showed an increase in tail flick latency which outlasted the period of restraint by 15 min. This restraint could be blocked but not reversed by 1 mg/kg of naltrexone hydrochloride given subcutaneously. Naltrexone methobromide, administered subcutaneously in doses of 10 or 25 mg/kg, did not block the analgesia indicating that peripheral opioid receptors were probably not involved. Naltrexone hydrochloride was shown to have no effect on brain tryptophan uptake in restrained rats, a neurochemical event which had previously been shown to be critical to restraint-induced analgesia.
长时间受束缚的大鼠甩尾潜伏期增加，且在束缚期结束后还持续了15分钟。皮下注射1毫克/千克盐酸纳曲酮可阻断这种束缚，但不能逆转。皮下注射剂量为10或25毫克/千克的甲溴酸纳曲酮不能阻断镇痛作用，这表明外周阿片受体可能未参与其中。结果显示，盐酸纳曲酮对受束缚大鼠的脑色氨酸摄取没有影响，而此前已证明这一神经化学事件对束缚诱导的镇痛作用至关重要。
