Kelly S J, Franklin K B
Neurosci Lett. 1984 Feb 24;44(3):305-10. doi: 10.1016/0304-3940(84)90040-5.
Morphine analgesia measured by the tail withdrawal test was examined in rats that were either restrained or left free during testing. It was found that restraint potentiated morphine analgesia and decreased the latency of the peak analgesic effect. Methysergide, a serotonin antagonist, and valine, which prevents the increase in brain tryptophan induced by restraint, blocked the effect of restraint on morphine analgesia. Valine did not alter analgesia in unrestrained rats. An increase in brain tryptophan uptake induced by stress is suggested as a possible mechanism by which stress can interact with pain modulation systems.
通过甩尾试验测定吗啡镇痛效果，对在测试过程中受到束缚或未受束缚的大鼠进行了研究。结果发现，束缚增强了吗啡镇痛作用，并缩短了镇痛峰值效应的潜伏期。5-羟色胺拮抗剂甲基麦角新碱和可防止束缚诱导脑内色氨酸增加的缬氨酸，阻断了束缚对吗啡镇痛的影响。缬氨酸并未改变未受束缚大鼠的镇痛效果。应激诱导脑内色氨酸摄取增加被认为是应激与疼痛调节系统相互作用的一种可能机制。
