Todorov D K, Silyanovska K K, Maneva K M, Ilarionova M V, Gantchev G T, Getov C M
Neoplasma. 1987;34(3):287-94.
The subcutaneous transplantable adenovirus sarcoma (TAVS) in hamsters was created in 1972 at the Oncological Research Institute and maintained by serial subcutaneous transplantation. It showed the highest sensitivity against some alkylating drugs and antimetabolites--cyclophosphamide, sarcolysine, methotrexate and 6-mercaptopurine. In some degree, TAVS is able to differentiate antitumor drugs of one group by the intensity of their antitumor activity. Among the drugs, cyclophosphamide was the most active and 6-mercaptopurine and 5-fluorouracil the least active. Antitumor drugs of plant origin, antibiotics and methyl-CCNU had a weak activity on subcutaneous TAVS. Intramuscular TAVS showed a similar sensitivity, with some differences for olivomycin, bruneomycin and vinblastine. Intracerebral TAVS was sensitive against antitumor agents penetrating through the hemato-encephalic barrier and which were active against its subcutaneous and intramuscular form. BCG vaccine and levamisole applied separately did not show any activity on the growth of TAVS. Combined immunochemotherapy with cyclophosphamide plus BCG gave a better enhancement of the antitumor effect of the cytostatic than that of the combination of methotrexate plus BCG and cyclophosphamide plus levamisole. These results showed that TAVS in hamsters may be used as a suitable experimental model for pharmacological studies of antitumor agents and combined immunochemotherapy.
仓鼠皮下可移植腺病毒肉瘤（TAVS）于1972年在肿瘤研究所培育而成，并通过连续皮下移植进行维持。它对某些烷化剂和抗代谢物——环磷酰胺、溶肉瘤素、甲氨蝶呤和6-巯基嘌呤表现出最高的敏感性。在某种程度上，TAVS能够根据抗肿瘤药物的抗肿瘤活性强度区分同一组中的不同药物。在这些药物中，环磷酰胺活性最强，6-巯基嘌呤和5-氟尿嘧啶活性最弱。植物来源的抗肿瘤药物、抗生素和甲基环己亚硝脲对皮下TAVS的活性较弱。肌肉内TAVS表现出类似的敏感性，对橄榄霉素、棕褐霉素和长春碱有一些差异。脑内TAVS对能够穿透血脑屏障且对其皮下和肌肉内形式有活性的抗肿瘤药物敏感。单独应用卡介苗（BCG）疫苗和左旋咪唑对TAVS的生长没有任何作用。环磷酰胺联合卡介苗的免疫化学疗法比甲氨蝶呤联合卡介苗以及环磷酰胺联合左旋咪唑的组合更能增强细胞抑制剂的抗肿瘤效果。这些结果表明，仓鼠中的TAVS可作为抗肿瘤药物药理研究和联合免疫化学疗法的合适实验模型。
