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猫的黑质-顶盖投射:一项电子显微镜放射自显影研究。

The nigrotectal projection in the cat: an electron microscope autoradiographic study.

作者信息

Behan M, Lin C S, Hall W C

出版信息

Neuroscience. 1987 May;21(2):529-39. doi: 10.1016/0306-4522(87)90139-4.

DOI:10.1016/0306-4522(87)90139-4
PMID:3039404
Abstract

Recent evidence indicates that the nigrotectal tract plays an important role in regulating the premotor responses of cells in the in the intermediate gray layer of the superior colliculus. The purpose of the present study was to characterize the ultrastructure of nigrotectal terminals and of their postsynaptic targets in the intermediate gray layer. Nigrotectal terminals were identified in the electron microscope by labeling them autoradiographically, following injections of tritiated proline into the substantia nigra pars reticulata. The majority of nigrotectal terminals contain a high proportion of pleomorphic vesicles and form symmetrical synaptic contacts. Most of these terminals synapse with small dendritic profiles (2.00 micron +/- 0.83 SD), which may be the distal dendrites of neurons in the intermediate gray layer. Less than 10% of the labeled contacts are made with cell bodies or initial axonal segments.

摘要

最近的证据表明,黑质顶盖束在调节上丘中间灰质层细胞的运动前反应中起重要作用。本研究的目的是描述黑质顶盖终末及其在中间灰质层的突触后靶点的超微结构。在将氚标记的脯氨酸注入黑质网状部后,通过放射自显影标记在电子显微镜下识别黑质顶盖终末。大多数黑质顶盖终末含有高比例的多形性囊泡,并形成对称的突触联系。这些终末大多与小的树突状轮廓(2.00微米±0.83标准差)形成突触,这些小的树突状轮廓可能是中间灰质层神经元的远端树突。少于10%的标记突触是与细胞体或轴突起始段形成的。

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