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碱催化的胺、单质硫和苯乙烯的三组分反应：无金属条件下硫代酰胺的合成

Base-Controlled Three Component Reactions of Amines, Elemental Sulfur, and Styrenes: Synthesis of Thioamides under Metal-Free Conditions.

作者信息

Zhang Pingshun, Chen Wanzhi, Liu Miaochang, Wu Huayue

机构信息

Department of Chemistry , Zhejiang University , Yuquan Campus, Hangzhou 310007 , China.

College of Chemistry and Materials Engineering , Wenzhou University , Wenzhou 325027 , China.

出版信息

J Org Chem. 2018 Dec 7;83(23):14269-14276. doi: 10.1021/acs.joc.8b01721. Epub 2018 Nov 13.

DOI:10.1021/acs.joc.8b01721
PMID:30394744
Abstract

Three component reactions of olefins, amines, and sulfur were studied. Thioamidation of styrenes is base-controlled, and 2-phenylethanethioamides and benzothioamides were obtained selectively in the presence of two different bases. This protocol offers a simple and efficient procedure for the synthesis of thioamides.

摘要

研究了烯烃、胺和硫的三组分反应。苯乙烯的硫代酰胺化反应受碱控制，在两种不同碱的存在下可选择性地得到2-苯基乙硫酰胺和苯并硫酰胺。该方法为硫代酰胺的合成提供了一种简单有效的途径。

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