Hubei Key Laboratory of Purification and Application of Plant Anti-Cancer Active Ingredients, Hubei University of Education, 129 Second Gaoxin Road, Wuhan 430205, China.
Univ Lyon, INSA Lyon, Université Claude Bernard Lyon 1, CNRS, UMR5246, ICBMS, Institut de Chimie et de Biochimie Moléculaires et Supramoléculaires, Bât. E. Lederer, 1 rue Victor Grignard, F-69622 Villeurbanne, France.
Molecules. 2023 Apr 17;28(8):3527. doi: 10.3390/molecules28083527.
Compounds possessing a thioamide function play a crucial role in organic synthesis, serving as key building blocks. They are also important in the pharmaceutical chemistry and drug design, owing to their ability to mimic the amide function in biomolecules while retaining or developing biological activity. From the synthetic viewpoint, several methods have been developed for preparing thioamides using sulfuration agents. The purpose of this review is to give an update of the last decade of contributions focusing on the formation of thioamides employing different sulfur sources. When appropriate, the cleanness and practicality of the new methods are highlighted.
含硫酰胺官能团的化合物在有机合成中起着至关重要的作用，它们是关键的构建模块。由于它们能够模拟生物分子中的酰胺功能，同时保持或发展生物活性，因此在药物化学和药物设计中也很重要。从合成的角度来看，已经开发出几种使用硫化剂制备硫代酰胺的方法。本文综述的目的是提供过去十年中使用不同硫源形成硫代酰胺的最新贡献，当合适时，突出新方法的清洁性和实用性。
