Fundación Para la Investigación Biomédica del Hospital Universitario de Getafe.
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III.
Curr Opin Clin Nutr Metab Care. 2019 Jan;22(1):52-57. doi: 10.1097/MCO.0000000000000535.
Disability and its preceding condition, frailty, are outstanding issues for achieving healthy aging. Diabetes is a very prevalent chronic disease among older patients that favours frailty status. This review will analyse the relationship between diabetes and frailty in the elderly and summarize the current strategies to improve physical function in diabetic older patients.
We have analyzed the current knowledge providing insight on the relationship between frailty and diabetes in older people. Epidemiological evidences and potential mechanisms connecting diabetes with frailty in the aging process have been examined. Finally, the strategies to reduce frailty in aged population with diabetes were discussed.
Current evidence reveals the high prevalence of diabetes in frail older patients, producing an additional impairment of physical performance in this population. Insulin resistance seems to contribute to this clinical manifestation which is related to the impact of diabetes on skeletal muscle function, on vascular function, and on the hormonal milieu. Exercise, nutritional and educational interventions, and less strict glycaemic control appear as the most effective strategies to reduce frailty in diabetic older people.
残疾及其前体状况——衰弱，是实现健康老龄化的突出问题。糖尿病是老年患者中非常普遍的慢性疾病，易导致衰弱状态。本综述将分析老年糖尿病患者中糖尿病与衰弱之间的关系，并总结改善老年糖尿病患者身体功能的当前策略。
我们分析了目前的知识，深入了解了老年人衰弱与糖尿病之间的关系。检查了连接糖尿病与衰老过程中衰弱的流行病学证据和潜在机制。最后，讨论了减少糖尿病老年人群衰弱的策略。
目前的证据表明，衰弱的老年患者中糖尿病的患病率很高，这会使该人群的身体机能进一步受损。胰岛素抵抗似乎促成了这种临床表现，这与糖尿病对骨骼肌功能、血管功能和激素环境的影响有关。运动、营养和教育干预以及较不严格的血糖控制似乎是减少老年糖尿病患者衰弱的最有效策略。
