Zhou Kunyan, Wang Ao, Yi Ke
Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.
Front Public Health. 2025 Apr 16;13:1565682. doi: 10.3389/fpubh.2025.1565682. eCollection 2025.
Cardiometabolic diseases are prevalent among ageing populations and have a close association with frailty. However, the cumulative impact multiple cardiometabolic diseases have on frailty remains underexplored.
This study used data from four international cohorts - HRS, CHARLS, ELSA and SHARE - to examine the correlation between frailty and cardiometabolic diseases (CMD). The frailty index was used for assessing frailty and statistical analyses were performed as a means of analysing the correlation between the number of cardiometabolic conditions and frailty severity. Linear regression models were employed to evaluate the associations between CMD and frailty severity.
The study found that as the number of cardiometabolic diseases increased, the frailty index rose significantly [one disease, = 7.80 (95% CI: 7.70 to 7.90) < 0.05; two diseases, = 17.92 (95% CI: 17.76 to 18.08) < 0.05; three diseases, β = 28.79 (95% CI: 28.41 to 29.17) < 0.05]. Stroke was found to have the most pronounced impact on frailty ( = 12.34 [95%CI 12.20 to 12.48] < 0.05) and the coexistence of multiple conditions served to amplify the symptoms of frailty.
This study highlights the compounded impact multiple cardiometabolic diseases have on frailty and also emphasizes the necessity for early intervention.
心脏代谢疾病在老年人群中普遍存在，且与衰弱密切相关。然而，多种心脏代谢疾病对衰弱的累积影响仍未得到充分研究。
本研究使用了来自四个国际队列（健康与退休研究、中国健康与养老追踪调查、英国老年纵向研究和健康、老龄化与退休调查）的数据，以检验衰弱与心脏代谢疾病（CMD）之间的相关性。衰弱指数用于评估衰弱情况，并进行统计分析以分析心脏代谢疾病数量与衰弱严重程度之间的相关性。采用线性回归模型评估CMD与衰弱严重程度之间的关联。
研究发现，随着心脏代谢疾病数量的增加，衰弱指数显著上升[一种疾病，β = 7.80（95%置信区间：7.70至7.90），P < 0.05；两种疾病，β = 17.92（95%置信区间：17.76至18.08），P < 0.05；三种疾病，β = 28.79（95%置信区间：28.41至29.17），P < 0.05]。中风被发现对衰弱的影响最为显著（β = 12.34 [95%置信区间12.20至12.48]，P < 0.05），多种疾病共存会加剧衰弱症状。
本研究强调了多种心脏代谢疾病对衰弱的复合影响，并强调了早期干预的必要性。
