Zhang Yuping, Gang Sha, Yu Wen
Department of General Practice, Beijing Tongren Hospital, Capital Medical University, Beijing, People's Republic of China.
Clin Interv Aging. 2025 May 29;20:751-762. doi: 10.2147/CIA.S503980. eCollection 2025.
Patients with type 2 diabetes mellitus (T2DM) have high risk of frailty. The clinical frailty scale (CFS) has been used to evaluate clinical frailty. To evaluate the association between CFS and visit-to-visit glycated hemoglobin (HbA1C) variability in T2DM patients.
Patients who were hospitalized with T2DM and received at least three HbA1C tests after discharging from endocrinology department and general practice department during 12-month follow-up were retrospectively enrolled. The patients were divided into the low-HbA1C variability group and the high-HbA1C variability group according to the results of the HbA1C variability score (HVS). The baseline clinical information, including CFS during hospitalization, was collected and compared between the two groups. We performed a propensity score match (PSM) to eliminate the influences of other confounding factors.
A total of 370 patients were included in this study. Most baseline demographic, clinical parameters and metabolic parameters were comparable between the two groups except age, baseline HbA1C, albumin, and comorbidities including hypertension and dyslipidemia between the two groups before PSM. All of the relative parameters were comparable after a 1:1 PSM. Uni-variable and multi-variable logistic analysis revealed that higher CFS was associated with higher HbA1C variability and receiver operating characteristic curve showed that CFS had good predictive value in HVS.
Higher CFS was associated with higher visit-to-visit HbA1C variability.
2型糖尿病（T2DM）患者存在较高的衰弱风险。临床衰弱量表（CFS）已被用于评估临床衰弱情况。本研究旨在评估T2DM患者中CFS与糖化血红蛋白（HbA1C）随访间变异性之间的关联。
回顾性纳入12个月随访期间因T2DM住院且在内分泌科和全科门诊出院后接受至少三次HbA1C检测的患者。根据HbA1C变异性评分（HVS）结果将患者分为低HbA1C变异性组和高HbA1C变异性组。收集两组患者的基线临床信息，包括住院期间的CFS，并进行比较。我们进行了倾向得分匹配（PSM）以消除其他混杂因素的影响。
本研究共纳入370例患者。在PSM之前，两组间除年龄、基线HbA1C、白蛋白以及包括高血压和血脂异常在内的合并症外，大多数基线人口统计学、临床参数和代谢参数具有可比性。经过1:1的PSM后，所有相关参数均具有可比性。单变量和多变量逻辑分析显示，较高的CFS与较高的HbA1C变异性相关，且受试者工作特征曲线表明CFS在HVS中具有良好的预测价值。
较高的CFS与较高的HbA1C随访间变异性相关。
