Ministry of Education and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China.
Department of Developmental and Behavioral Pediatrics, Shanghai Pediatric Transitional Institution, Shanghai Children's Medical Center affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
BMC Pediatr. 2018 Nov 5;18(1):344. doi: 10.1186/s12887-018-1328-z.
Assessment of child growth is important in detecting under- and over-growth. We aimed to examine the growth patterns of healthy Chinese infants from birth to 24 months.
This study was based on six recent birth cohorts across China, which provided data (from 2015) on 4251 children (2174 boys, 2077 girls) who were born at term to mothers without gestational or preexisting diabetes, chronic hypertension, preeclampsia, or eclampsia. Analyses were performed using 28,298 longitudinal anthropometric measures in 4251 children and the LMS method to generate smoothed Z-score growth curves, which were compared to the WHO growth standards (which are based on data from 2003) and current Chinese growth references (which are based on data from 2005).
Most (80.3%) of mother had college education or more, and maternal smoking was rare (0.4%). Compared to the WHO longitudinal growth standards for children aged 0 to 2 years, the growth references from this longitudinal study (length-, weight-, head circumference-, BMI-for-age, and weight-for-length) were significantly higher, for boys and girls; Specifically, the median length-, weight-, head circumference-, BMI-for-age, and weight-for-length was on average 0.9 (range 0.2-1.3) cm, 0.51 (range 0.09-0.74) kg, 0.17 (range - 0.24 to 0.37) cm, 0.70 (range 0.01 to 0.92) kg/m, and 0.43 (range 0.01 to 1.07) kg higher in Chinese boys, and 1.3 (range 0.5-1.9) cm, 0.73 (range 0.10-0.91) kg, 0.45 (range 0.15-0.62) cm, 0.7 (range 0.0 to 1.0) kg/m, and 0.42 (range 0.00 to 0.64) kg greater in Chinese girls, respectively. Compared to the current China cross-sectional growth references (based on data from a decade ago), growth references from this study were also higher, but the difference was less than that between growth references of this study and WHO growth standards.
This recent multicenter prospective birth cohort study examined early growth patterns in China. The new growth curves represent the growth patterns of healthy Chinese infants evaluated longitudinally from 0 to 24 months of age, and provide references for monitoring growth in early life in modern China that are more recent than WHO longitudinal growth standards from other countries and previous cross-sectional growth references for China.
评估儿童生长发育对于发现生长不足和生长过度非常重要。本研究旨在探讨健康中国婴儿从出生到 24 个月的生长模式。
本研究基于中国的 6 项近期出生队列研究，共纳入了 4251 名（男婴 2174 名，女婴 2077 名）足月出生、母亲无妊娠期或孕前糖尿病、慢性高血压、子痫前期或子痫的儿童的数据（来自 2015 年）。对 4251 名儿童的 28298 次纵向人体测量数据进行分析，并使用 LMS 方法生成平滑 Z 评分生长曲线，将其与世界卫生组织（WHO）的生长标准（基于 2003 年的数据）和当前中国的生长参考值（基于 2005 年的数据）进行比较。
大多数（80.3%）母亲受过大学教育或以上，母亲吸烟的情况很少（0.4%）。与 WHO 0-2 岁儿童的纵向生长标准相比，本纵向研究的生长参考值（长度、体重、头围、年龄别 BMI 和身长别体重）在男孩和女孩中均显著更高；具体而言，中国男孩的平均长度、体重、头围、年龄别 BMI 和身长别体重分别高出 0.9（范围 0.2-1.3）cm、0.51（范围 0.09-0.74）kg、0.17（范围-0.24 至 0.37）cm、0.70（范围 0.01 至 0.92）kg/m 和 0.43（范围 0.01 至 1.07）kg，中国女孩的平均长度、体重、头围、年龄别 BMI 和身长别体重分别高出 1.3（范围 0.5-1.9）cm、0.73（范围 0.10-0.91）kg、0.45（范围 0.15-0.62）cm、0.7（范围 0.0 至 1.0）kg/m 和 0.42（范围 0.00 至 0.64）kg。与当前中国的横断面生长参考值（基于 10 年前的数据）相比，本研究的生长参考值也更高，但与本研究的生长参考值与 WHO 生长标准之间的差异相比，差异较小。
本研究最近进行的多中心前瞻性出生队列研究探讨了中国的早期生长模式。新的生长曲线代表了中国健康婴儿从 0 至 24 个月的纵向生长模式，为监测现代中国生命早期的生长提供了比 WHO 其他国家的纵向生长标准和中国以前的横断面生长参考值更新的参考值。
