PROX1与胃癌的癌症进展和预后相关。
PROX1 Is Associated with Cancer Progression and Prognosis in Gastric Cancer.
作者信息
Ueta Koji, Otowa Yasunori, Kakeji Yoshihiro, Hirashima Masanori
机构信息
Division of Vascular Biology, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan
Division of Gastro-intestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
出版信息
Anticancer Res. 2018 Nov;38(11):6139-6145. doi: 10.21873/anticanres.12966.
BACKGROUND
It was recently reported that expression of prospero homeobox protein-1 (PROX1) is correlated with the prognosis of esophageal cancer and colorectal cancer. However, its correlation with gastric cancer is unclear.
MATERIALS AND METHODS
Our study analyzed the effect of PROX1 knockdown on the migration, invasion and proliferation of the MKN45 human gastric cancer cell line. The correlation between PROX1 expression levels and clinicopathological factors were also analyzed in tumor samples from 99 patients with gastric cancer.
RESULTS
Migration, invasion and proliferation were significantly reduced in MKN45 cells with PROX1 knockdown. PROX1 expression was detected in gastric cancer tissues at various levels. PROX1 expression levels were positively correlated with cancer stage, N factor, lymphatic vascular invasion, and vascular invasion in patients with gastric cancer. Analysis of overall and recurrence-free survival indicated that high PROX1 expression was significantly correlated with poor prognosis.
CONCLUSION
PROX1 can be an indicator of poor prognosis and a molecular target for gastric cancer treatment.
背景
最近有报道称，prospero同源盒蛋白1（PROX1）的表达与食管癌和结直肠癌的预后相关。然而，其与胃癌的相关性尚不清楚。
材料与方法
我们的研究分析了PROX1基因敲低对MKN45人胃癌细胞系迁移、侵袭和增殖的影响。还分析了99例胃癌患者肿瘤样本中PROX1表达水平与临床病理因素之间的相关性。
结果
PROX1基因敲低的MKN45细胞的迁移、侵袭和增殖显著降低。在不同水平的胃癌组织中均检测到PROX1表达。PROX1表达水平与胃癌患者的癌症分期、N因子、淋巴管侵犯和血管侵犯呈正相关。总生存和无复发生存分析表明，PROX1高表达与预后不良显著相关。
结论
PROX1可作为预后不良的指标和胃癌治疗的分子靶点。
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