Department of Thoracic Surgery, Hebei Medical University Fourth Affiliated Hospital, Shijiazhuang, 050001, Hebei, People's Republic of China.
Department of Epidemiology and Statistics, School of Public Health, Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang, 050017, People's Republic of China.
Sci Rep. 2023 Aug 1;13(1):12494. doi: 10.1038/s41598-023-39784-1.
Inhibin subunit beta A (INHBA) is a member of the transforming growth factor-beta (TGF-β) superfamily that plays a fundamental role in various cancers. However, a systematic analysis of the exact role of INHBA in patients with gastric cancer (GC) has not yet been conducted. We evaluated the expression levels of INHBA and the correlation between INHBA and GC prognosis in GC. The relationship between INHBA expression, immune infiltration levels, and type markers of immune cells in GC was also explored. In addition, we studied INHBA mutations, promoter methylation, and functional enrichment analysis. Besides, high expression levels of INHBA in GC were significantly related to unfavorable prognosis. INHBA was negatively correlated with B cell infiltration, but positively correlated with macrophage and most anticancer immunity steps. INHBA expression was positively correlated with the type markers of CD8+ T cells, neutrophils, macrophages, and dendritic cells. INHBA has a weak significant methylation level change between tumor and normal tissues and mainly enriched in cancer-related signaling pathways. The present study implies that INHBA may serve as a potential biomarker for predicting the prognosis of patients with GC. INHBA is a promising predictor of immunotherapy response, with higher levels of INHBA indicating greater sensitivity.
抑制素亚基β A (INHBA) 是转化生长因子-β (TGF-β) 超家族的成员，在各种癌症中发挥着重要作用。然而，目前尚未对 INHBA 在胃癌 (GC) 患者中的确切作用进行系统分析。我们评估了 INHBA 的表达水平以及 INHBA 与 GC 预后之间的相关性。还探讨了 INHBA 表达与 GC 中免疫浸润水平和免疫细胞类型标志物之间的关系。此外，我们研究了 INHBA 突变、启动子甲基化和功能富集分析。此外，GC 中 INHBA 的高表达水平与不良预后显著相关。INHBA 与 B 细胞浸润呈负相关，但与巨噬细胞和大多数抗癌免疫步骤呈正相关。INHBA 表达与 CD8+T 细胞、中性粒细胞、巨噬细胞和树突状细胞的类型标志物呈正相关。INHBA 在肿瘤组织和正常组织之间的甲基化水平变化较弱且显著，主要富集在癌症相关信号通路中。本研究表明，INHBA 可能作为预测 GC 患者预后的潜在生物标志物。INHBA 是免疫治疗反应的有前途的预测因子，INHBA 水平较高表明对免疫治疗更敏感。
