骨质疏松症在肝硬化中的影响：特别参考随年龄变化的标准骨密度
Impact of Osteopenia in Liver Cirrhosis: Special Reference to Standard Bone Mineral Density with Age.
作者信息
Toshima Takeo, Yoshizumi Tomoharu, Ikegami Toru, Harada Noboru, Itoh Shinji, Mano Yohei, Motomura Takashi, Soejima Yuji, Maehara Yoshihiko
机构信息
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
出版信息
Anticancer Res. 2018 Nov;38(11):6465-6471. doi: 10.21873/anticanres.13009.
BACKGROUND/AIM: Computed tomography (CT) has recently been applied to measure bone mineral density (BMD). However, the definition of osteopenia, which means depletion of BMD, using CT remains controversial. The aim of this study was to establish formulae to calculate standard BMD.
PATIENTS AND METHODS
Fifty healthy donors for liver transplantation underwent CT. BMD was measured as cross-sectional average pixel density (Hounsfield units) only in trabecular-bone at Th11 bottom. Validation was performed on another 50 healthy donors to check the accuracy of formulae for standard BMD.
RESULTS
Measured BMD was significantly correlated with age in both males and females (p<0.0001). The formulae to calculate standard BMD were 308.82-2.49 × Age in males and 311.84-2.41 × Age in females. Estimated BMD was significantly correlated with measured BMD in males and females (p<0.0001).
CONCLUSION
Osteopenia can be defined by the difference between measured data and calculated data using our new formula based on each age.
背景/目的：计算机断层扫描（CT）最近已被用于测量骨密度（BMD）。然而，使用CT对骨质减少（即BMD降低）的定义仍存在争议。本研究的目的是建立计算标准BMD的公式。
患者与方法
50名健康的肝移植供体接受了CT检查。仅在第11胸椎底部的小梁骨中测量BMD，以横断面平均像素密度（亨氏单位）表示。在另外50名健康供体上进行验证，以检查标准BMD公式的准确性。
结果
男性和女性的测量BMD均与年龄显著相关（p<0.0001）。计算标准BMD的公式在男性为308.82 - 2.49×年龄，在女性为311.84 - 2.41×年龄。估计BMD与男性和女性的测量BMD均显著相关（p<0.0001）。
结论
骨质减少可以通过使用我们基于各年龄的新公式，由测量数据与计算数据之间的差异来定义。
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