Department of Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada.
Department of Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada
J Immunol. 2018 Nov 15;201(10):2855-2861. doi: 10.4049/jimmunol.1800805.
Recent reports suggest a quorum of T cells is required to activate T lymphocytes and that this requirement may help explain why scarce lymphocytes, specific for peripheral self-antigen, are rarely activated by Ag. This proposal runs counter to the commonly held framework that the Ag-dependent, but CD4 T lymphocyte-independent, activation of CD8 T lymphocytes, and the activation of CD4 T lymphocytes themselves, can occur when a single CD8 or CD4 T lymphocyte encounters Ag under appropriately dangerous circumstances. We argue that a review of older literature often ignored, as well as of contemporary studies, supports the quorum concept and is difficult to reconcile with the Danger Model.
最近的报告表明，T 细胞需要达到一定的群体数量才能激活 T 淋巴细胞，这一需求可能有助于解释为什么针对外周自身抗原的稀有淋巴细胞很少被抗原激活。这一观点与普遍持有的观点相悖，即公认的框架认为，在适当危险的情况下，当单个 CD8 或 CD4 T 淋巴细胞遇到抗原时，CD8 T 淋巴细胞的 Ag 依赖性但 CD4 T 淋巴细胞非依赖性激活，以及 CD4 T 淋巴细胞自身的激活都可以发生。我们认为，对旧文献的审查往往被忽视，以及对当代研究的审查，支持群体数量的概念，并且与危险模型难以调和。
