Department of Biochemistry, Microbiology and Immunology, Health Sciences Building, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada.
Int J Mol Sci. 2023 Jan 18;24(3):1887. doi: 10.3390/ijms24031887.
Rational vaccination against and immunotherapy of any infectious disease requires knowledge of how protective and non-protective immune responses differ, and how immune responses are regulated, so their nature can be controlled. Strong Th1 responses are likely protective against Understanding how immune class regulation is achieved is pertinent to both vaccination and treatment. I argue that variables of infection, other than PAMPs, primarily determine the class of immunity generated. The alternative, non-PAMP framework I favour, allows me to propose strategies to achieve efficacious vaccination, transcending host and pathogen genetic variability, to prevent tuberculosis, and personalised protocols to treat disease.
理性的疫苗接种和任何传染病的免疫治疗都需要了解保护性和非保护性免疫反应的区别，以及免疫反应是如何调节的，从而控制其性质。强烈的 Th1 反应可能对理解免疫类别的调节是如何实现的与疫苗接种和治疗都有关。我认为，除了 PAMPs 之外，感染的变量主要决定了产生的免疫类型。我赞成的非 PAMP 框架使我能够提出策略来实现有效的疫苗接种，克服宿主和病原体遗传变异性，以预防结核病，并制定个性化的治疗方案。
