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Tumors sweeten macrophages with acids.

作者信息

Sekine Hiroki, Yamamoto Masayuki, Motohashi Hozumi

机构信息

Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.

出版信息

Nat Immunol. 2018 Dec;19(12):1281-1283. doi: 10.1038/s41590-018-0258-0.

DOI:10.1038/s41590-018-0258-0
PMID:30397351
Abstract
摘要

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Tumors sweeten macrophages with acids.肿瘤通过酸性物质使巨噬细胞“变甜”。
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Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages.肿瘤通过酸中毒依赖性诱导调节性肿瘤相关巨噬细胞实现免疫逃逸。
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