Kin Cindy
Department of Surgery, Stanford University School of Medicine, Stanford, California.
Clin Colon Rectal Surg. 2018 Nov;31(6):353-360. doi: 10.1055/s-0038-1668105. Epub 2018 Nov 2.
Squamous cell carcinomas of the anal canal and the anal margin are rare malignancies that are increasing in incidence. Patients with these tumors often experience delayed treatment due to delay in diagnosis or misdiagnosis of the condition. Distinguishing between anal canal and anal margin tumors has implications for staging and treatment. Chemoradiation therapy is the mainstay of treatment for anal canal squamous cell, with abdominoperineal resection reserved for salvage treatment in cases of persistent or recurrent disease. Early anal margin squamous cell carcinoma can be treated with wide local excision, but more advanced tumors require a combination of chemoradiation therapy and surgical excision.
肛管和肛缘鳞状细胞癌是罕见的恶性肿瘤，其发病率正在上升。这些肿瘤患者常因诊断延迟或误诊而导致治疗延误。区分肛管肿瘤和肛缘肿瘤对分期和治疗具有重要意义。放化疗是肛管鳞状细胞癌的主要治疗方法，腹会阴联合切除术仅用于持续性或复发性疾病的挽救治疗。早期肛缘鳞状细胞癌可采用广泛局部切除治疗，但更晚期的肿瘤则需要放化疗与手术切除相结合。
