Hardy K J, Hughes E S R, Cuthbertson A M
University of Melbourne Department of Surgery, Austin Hospital and Royal Melbourne Hospital.
Aust N Z J Surg. 1972 May;38(4):301-305. doi: 10.1111/j.1445-2197.1972.tb05642.x.
This is a study of 41 patients with squamous carcinoma of the anus. There were 23 with a carcinoma situated above the dentate line, the five-year survival rate being 27%, and 18 with a carcinoma below the dentate line, with a five-year survival rate of 30%. Advanced local and lymphatic spread at the initial examination was a prominent feature of the series.
The records of 41 patients with squamous cell carcinoma of the anal canal and anal margin are reviewed. An exact follow-up study was possible in every instance. There were 23 individuals with carcinoma of the anal canal and 18 with carcinoma of the anal margin. Spread to local structures or lymph nodes was observed in nearly half of the patients with anal canal carcinoma, and less frequently in anal margin carcinoma. The preferred method of treatment for anal canal carcinoma was a Miles abdominoperineal resection, and for anal margin carcinoma wide local excision. The combined five-year survival was 28.6%, being 27% for anal canal carcinoma, and 30.5% for anal margin carcinoma.
这是一项针对41例肛管鳞状细胞癌患者的研究。其中23例癌位于齿状线以上，五年生存率为27%；18例癌位于齿状线以下，五年生存率为30%。初次检查时局部及淋巴转移进展是该系列病例的一个显著特征。
回顾了41例肛管和肛缘鳞状细胞癌患者的病历。每例均进行了确切的随访研究。其中23例为肛管癌，18例为肛缘癌。近一半的肛管癌患者观察到有局部结构或淋巴结转移，而肛缘癌患者中这种情况较少见。肛管癌的首选治疗方法是腹会阴联合切除术（Miles手术），肛缘癌则行广泛局部切除术。联合五年生存率为28.6%，其中肛管癌为27%，肛缘癌为30.5%。
