感染复数是西南太平洋地区村庄层面和人群患病率的不良预测指标。
Multiplicity of Infection Is a Poor Predictor of Village-Level and Population Prevalence in the Southwest Pacific.
作者信息
Koepfli Cristian, Waltmann Andreea, Ome-Kaius Maria, Robinson Leanne J, Mueller Ivo
机构信息
Population Health & Immunity Division, Walter & Eliza Hall Institute, Parkville, Australia.
Department of Medical Biology, University of Melbourne, Parkville, Australia.
出版信息
Open Forum Infect Dis. 2018 Sep 21;5(11):ofy240. doi: 10.1093/ofid/ofy240. eCollection 2018 Nov.
Across 8101 individuals in 46 villages, the proportion of spp. multiple clone infections (0%-53.8%) did not reflect prevalence by quantitative polymerase chain reaction (qPCR; 1.9%-38.4%), except for in Solomon Islands ( < .001). Thus this parameter was not informative to identify transmission foci. In contrast, prevalence by microscopy and qPCR correlated well.
在46个村庄的8101个人中，除了所罗门群岛的某物种外（P<0.001），该物种多重克隆感染的比例（0%-53.8%）与定量聚合酶链反应（qPCR）得出的流行率（1.9%-38.4%）并不相符。因此，这个参数对于识别传播病灶并无参考价值。相比之下，显微镜检查得出的流行率与qPCR得出的流行率相关性良好。
Zotero 插件