Watanabe H, Katsuda S, Okada Y, Ooi A, Ueno H
Acta Pathol Jpn. 1987 Apr;37(4):685-92. doi: 10.1111/j.1440-1827.1987.tb00403.x.
A case of pleomorphic adenoma of the vagina in a 44-year-old woman was described. The tumor was a submucosal mass measuring 3.5 X 2 X 2 cm and located in the left lateral wall 1.5 cm inside the introitus. Histologically, it was predominantly composed of sheets and strands of spindle-shaped or polygonal cells focally dispersed in the myxoid tissue to form pseudomicrocysts. Ultrastructure demonstrated the basal lamina, desmosomes, variable amounts of filaments of both intermediate and microfilament, and occasionally microvilli in these tumor cells indicating that dominant cells were myoepithelial in nature. With immunohistochemical studies, keratin and cytokeratin were positive, whereas, S-100 protein, glial fibrillary acidic protein, vimentin, secretory component, and lysozyme were negative. The previously published cases were reviewed and compared with the present case.
描述了一名44岁女性阴道多形性腺瘤的病例。肿瘤为黏膜下肿物，大小为3.5×2×2 cm，位于阴道口内1.5 cm处的左侧壁。组织学上，它主要由梭形或多边形细胞片和条索组成，局灶性散在于黏液样组织中形成假微囊肿。超微结构显示这些肿瘤细胞中有基膜、桥粒、数量不等的中间丝和微丝，偶尔还有微绒毛，表明主要细胞本质上是肌上皮细胞。免疫组化研究显示，角蛋白和细胞角蛋白呈阳性，而S-100蛋白、胶质纤维酸性蛋白、波形蛋白、分泌成分和溶菌酶呈阴性。回顾了先前发表的病例并与本病例进行了比较。
