基于细胞的关节镜半月板再生一期手术的可行性：尸体研究。
Surgical Feasibility of a One-Stage Cell-Based Arthroscopic Procedure for Meniscus Regeneration: A Cadaveric Study.
机构信息
1 Department of Orthopaedics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
2 Department of Anatomy, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
出版信息
Tissue Eng Part C Methods. 2018 Dec;24(12):688-696. doi: 10.1089/ten.TEC.2018.0240.
Abstract
Meniscus injury remains the most common indication for orthopedic surgery, but loss of functioning meniscus tissue is strongly correlated with development of early osteoarthritis. However, current clinical options for tissue engineering of the meniscus are limited. This study demonstrates the feasibility of combining human meniscus cells with mesenchymal stromal cells to enhance a meniscus scaffold for meniscus regeneration in a one-stage solution for partial meniscal deficiency.
摘要
半月板损伤仍然是骨科手术最常见的指征，但半月板功能丧失与早期骨关节炎的发展密切相关。然而，目前用于半月板组织工程的临床选择有限。本研究证明了将人半月板细胞与间充质基质细胞结合以增强半月板支架用于部分半月板缺失的半月板再生的一个阶段解决方案的可行性。
相似文献
1
Surgical Feasibility of a One-Stage Cell-Based Arthroscopic Procedure for Meniscus Regeneration: A Cadaveric Study.基于细胞的关节镜半月板再生一期手术的可行性：尸体研究。
Tissue Eng Part C Methods. 2018 Dec;24(12):688-696. doi: 10.1089/ten.TEC.2018.0240.
2
Meniscus regeneration combining meniscus and mesenchymal stromal cells in a degradable meniscus implant: an in vitro study.半月板和间充质基质细胞联合构建可降解半月板植入物促进半月板再生：一项体外研究。
Eur Cell Mater. 2019 Aug 12;38:51-62. doi: 10.22203/eCM.v038a05.
3
A clinical study of collagen meniscus implants to restore the injured meniscus.胶原蛋白半月板植入物修复损伤半月板的临床研究。
Clin Orthop Relat Res. 1999 Oct(367 Suppl):S281-92. doi: 10.1097/00003086-199910001-00027.
4
Autologous mesenchymal stem cells or meniscal cells: what is the best cell source for regenerative meniscus treatment in an early osteoarthritis situation?自体间充质干细胞或半月板细胞：在早期骨关节炎情况下，哪种细胞是再生性半月板治疗的最佳细胞来源？
Stem Cell Res Ther. 2017 Oct 10;8(1):225. doi: 10.1186/s13287-017-0678-z.
5
PCL-MECM-Based Hydrogel Hybrid Scaffolds and Meniscal Fibrochondrocytes Promote Whole Meniscus Regeneration in a Rabbit Meniscectomy Model.基于 PCL-MECM 的水凝胶杂化支架和半月板纤维软骨细胞促进兔半月板切除术模型中的全半月板再生。
ACS Appl Mater Interfaces. 2019 Nov 6;11(44):41626-41639. doi: 10.1021/acsami.9b13611. Epub 2019 Oct 22.
6
Comparison of the collagen meniscus implant with partial meniscectomy. A prospective randomized trial.胶原蛋白半月板植入物与部分半月板切除术的比较。一项前瞻性随机试验。
J Bone Joint Surg Am. 2008 Jul;90(7):1413-26. doi: 10.2106/JBJS.G.00656.
7
The regenerative effect of different growth factors and platelet lysate on meniscus cells and mesenchymal stromal cells and proof of concept with a functionalized meniscus implant.不同生长因子和血小板裂解液对半月板细胞和间充质基质细胞的再生作用及功能化半月板植入物的概念验证。
J Tissue Eng Regen Med. 2021 Jul;15(7):648-659. doi: 10.1002/term.3218. Epub 2021 May 21.
8
Current strategies in meniscal regeneration.半月板再生的当前策略。
J Biomed Mater Res B Appl Biomater. 2014 Apr;102(3):619-34. doi: 10.1002/jbm.b.33030. Epub 2013 Sep 13.
9
Biomechanical Stimulus Based Strategies for Meniscus Tissue Engineering and Regeneration.基于生物力学刺激的半月板组织工程与再生策略。
Tissue Eng Part B Rev. 2018 Oct;24(5):392-402. doi: 10.1089/ten.TEB.2017.0508.
10
Tissue-engineered collagen meniscus implants: 5- to 6-year feasibility study results.组织工程化胶原蛋白半月板植入物：5至6年可行性研究结果
Arthroscopy. 2005 May;21(5):515-25. doi: 10.1016/j.arthro.2005.01.006.
引用本文的文献
1
Collagen-Based Products in Wound, Skin, and Health Care.用于伤口、皮肤及医疗保健的胶原蛋白类产品。
Adv Wound Care (New Rochelle). 2025 Jul 28. doi: 10.1177/21621918251361118.
2
From IMPACT to RECLAIM: A Single-Stage Cell Therapy for Articular Cartilage Repair and a Platform for Musculoskeletal Tissue Regeneration.从IMPACT到RECLAIM：用于关节软骨修复的单阶段细胞疗法及肌肉骨骼组织再生平台。
Curr Rev Musculoskelet Med. 2025 Apr;18(4):133-139. doi: 10.1007/s12178-025-09949-8. Epub 2025 Feb 11.
3
Potential of Melt Electrowritten Scaffolds Seeded with Meniscus Cells and Mesenchymal Stromal Cells.熔融静电纺丝支架培养半月板细胞和间充质基质细胞的潜力。
Int J Mol Sci. 2021 Oct 18;22(20):11200. doi: 10.3390/ijms222011200.
4
Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues.对骨关节炎供体匹配组织进行组织学分析，以表征区域性半月板细胞和软骨细胞表型及软骨分化。
Sci Rep. 2020 Dec 10;10(1):21658. doi: 10.1038/s41598-020-78757-6.
本文引用的文献
1
Mesenchymal Stromal/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration .间质基质/干细胞衍生的细胞外囊泡促进人软骨再生。
Theranostics. 2018 Jan 1;8(4):906-920. doi: 10.7150/thno.20746. eCollection 2018.
2
Allogeneic MSCs and Recycled Autologous Chondrons Mixed in a One-Stage Cartilage Cell Transplantion: A First-in-Man Trial in 35 Patients.同种异体间充质干细胞与回收自体软骨粒混合进行一期软骨细胞移植：35例患者的首例人体试验
Stem Cells. 2017 Aug;35(8):1984-1993. doi: 10.1002/stem.2657. Epub 2017 Jun 23.
3
Cell-Based Meniscus Repair and Regeneration: At the Brink of Clinical Translation?: A Systematic Review of Preclinical Studies.基于细胞的半月板修复与再生：临床转化的边缘？：临床前研究的系统综述
Orthop J Sports Med. 2017 Feb 21;5(2):2325967117690131. doi: 10.1177/2325967117690131. eCollection 2017 Feb.
4
Randomized Comparison of Allogeneic Versus Autologous Mesenchymal Stem Cells for Nonischemic Dilated Cardiomyopathy: POSEIDON-DCM Trial.异基因与自体间充质干细胞治疗非缺血性扩张型心肌病的随机对照研究：POSEIDON-DCM试验
J Am Coll Cardiol. 2017 Feb 7;69(5):526-537. doi: 10.1016/j.jacc.2016.11.009. Epub 2016 Nov 14.
5
Allogeneic Mesenchymal Stem Cells Stimulate Cartilage Regeneration and Are Safe for Single-Stage Cartilage Repair in Humans upon Mixture with Recycled Autologous Chondrons.同种异体间充质干细胞与回收的自体软骨颗粒混合后可刺激软骨再生，且对人类单阶段软骨修复是安全的。
Stem Cells. 2017 Jan;35(1):256-264. doi: 10.1002/stem.2475. Epub 2016 Aug 29.
6
A Synthetic Thermosensitive Hydrogel for Cartilage Bioprinting and Its Biofunctionalization with Polysaccharides.一种用于软骨生物打印的合成热敏水凝胶及其多糖生物功能化
Biomacromolecules. 2016 Jun 13;17(6):2137-2147. doi: 10.1021/acs.biomac.6b00366. Epub 2016 May 24.
7
The role of meniscal tissue in joint protection in early osteoarthritis.半月板组织在早期骨关节炎关节保护中的作用。
Knee Surg Sports Traumatol Arthrosc. 2016 Jun;24(6):1763-74. doi: 10.1007/s00167-016-4069-2. Epub 2016 Apr 16.
8
Autologous, allogeneic, induced pluripotent stem cell or a combination stem cell therapy? Where are we headed in cartilage repair and why: a concise review.自体、异体、诱导多能干细胞还是联合干细胞疗法？我们在软骨修复方面的发展方向以及原因：简要综述
Stem Cell Res Ther. 2015 May 15;6(1):94. doi: 10.1186/s13287-015-0086-1.
9
Resorbable collagen scaffolds for the treatment of meniscus defects: a systematic review.用于治疗半月板缺损的可吸收胶原支架：一项系统评价
Arthroscopy. 2015 May;31(5):927-41. doi: 10.1016/j.arthro.2014.11.019. Epub 2015 Jan 14.
10
The human meniscus: a review of anatomy, function, injury, and advances in treatment.人类半月板：解剖学、功能、损伤及治疗进展综述
Clin Anat. 2015 Mar;28(2):269-87. doi: 10.1002/ca.22456. Epub 2014 Aug 14.
Zotero 插件