Bitter Taste Receptors: Taking a Bigger Bite of Airway Smooth Muscle Pathophysiology.
作者信息
Emala Charles W
机构信息
1 Department of Anesthesiology Columbia University New York, New York.
出版信息
Am J Respir Cell Mol Biol. 2019 May;60(5):492-493. doi: 10.1165/rcmb.2018-0354ED.
Abstract
摘要
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Bitter Taste Receptors: Taking a Bigger Bite of Airway Smooth Muscle Pathophysiology.苦味受体：深入探究气道平滑肌病理生理学
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本文引用的文献
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Biased TAS2R Bronchodilators Inhibit Airway Smooth Muscle Growth by Downregulating Phosphorylated Extracellular Signal-regulated Kinase 1/2.偏 TAS2R 激动剂通过下调磷酸化细胞外信号调节激酶 1/2 抑制气道平滑肌生长。
Am J Respir Cell Mol Biol. 2019 May;60(5):532-540. doi: 10.1165/rcmb.2018-0189OC.
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Taste and smell GPCRs in the lung: Evidence for a previously unrecognized widespread chemosensory system.肺部的味觉和嗅觉 GPCRs：一个以前未被认识的广泛化学感觉系统的证据。
Cell Signal. 2018 Jan;41:82-88. doi: 10.1016/j.cellsig.2017.02.002. Epub 2017 Feb 4.
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Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via G.气道平滑肌苦味受体与细胞内信号传导及舒张的偶联是通过G蛋白实现的。
Am J Respir Cell Mol Biol. 2017 Jun;56(6):762-771. doi: 10.1165/rcmb.2016-0373OC.
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Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells.苦味受体激动剂对气道平滑肌细胞的抗有丝分裂作用。
Am J Physiol Lung Cell Mol Physiol. 2016 Feb 15;310(4):L365-76. doi: 10.1152/ajplung.00373.2015. Epub 2015 Dec 18.
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NMDA receptors mediate contractile responses in human airway smooth muscle cells.N-甲基-D-天冬氨酸受体介导人类气道平滑肌细胞中的收缩反应。
Am J Physiol Lung Cell Mol Physiol. 2015 Jun 15;308(12):L1253-64. doi: 10.1152/ajplung.00402.2014. Epub 2015 Apr 17.
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Bitter taste receptor function in asthmatic and nonasthmatic human airway smooth muscle cells.哮喘和非哮喘患者气道平滑肌细胞中苦味受体的功能。
Am J Respir Cell Mol Biol. 2014 Apr;50(4):678-83. doi: 10.1165/rcmb.2013-0439RC.
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Extraoral bitter taste receptors as mediators of off-target drug effects.口腔外苦味受体作为药物脱靶效应的介体。
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